Omrazol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (4 x 5: ৳ 160.00)

Strip Price: ৳ 40.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Ad din pharmaceuticals ltd
Also available as	Omrazol 20 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell.

Dosage

Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed
Long-term management of acid reflux disease: 10-20 mg daily
Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents as detailed in product information
Pediatric use in severe ulcerating reflux esophagitis (Child>1 year): Varying dosage based on body-weight
IV Injection dosage for specific indications

Administration

Direction for use of IV Injection
Direction for use of IV Infusion

Interaction

Decreased intragastric acidity affecting absorption of ketoconazole
Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
No evidence of interaction with certain medications, alcohol, or food

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it. Malignancy should be excluded before treatment if gastric ulcer is suspected.

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
Diarrhoea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
Other gastrointestinal reactions and isolated cases of adverse effects

Pregnancy & Lactation

Results from prospective epidemiological studies indicate no adverse effects on pregnancy or on the health of the fetus/newborn child
No information available on the passage of Omeprazole into breast milk or its effects on the neonate
Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

Avoid concomitant use of clopidogrel
Observational studies suggest an increased risk for osteoporosis-related fractures
Atrophic gastritis noted occasionally in long-term treatment
Concomitant use of PPIs with methotrexate may lead to toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.