Omsec 40 mg/vial (IV Injection)

40 mg vial: ৳ 69.68

Medicine Details

Category Details
Generic Omeprazole
Company Techno drugs ltd
Also available as
Omsec 20 mg capsule Omsec 40 mg capsule

Indications

  • Treatment of Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours
  • Slow return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Different dosages for specific conditions
  • Oral and IV administration options
  • Ranges from 10mg to 120mg depending on condition and patient weight
  • Specific regimen for Helicobacter pylori eradication
  • Different protocols for pediatric use

Administration

  • IV Injection and IV Infusion directions
  • Specific instructions for reconstitution and administration
  • Use within specified time after reconstitution
  • Precautions for co-administration with other drugs

Interaction

  • Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, and antimicrobial agents
  • No interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen, and digoxin
  • Increased bioavailability of digoxin with simultaneous treatment

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Reports of skin rash, urticaria, pruritus, photosensitivity, bullous eruption, and alopecia
  • Gastrointestinal reactions including diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Reports of dry mouth, stomatitis, candidiasis, paraesthesia, and dizziness
  • Reversible mental confusion, agitation, depression, and hallucinations in severely ill patients

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • No information on passage into breast milk or effects on the neonate
  • Discontinuation of breast-feeding if omeprazole use is essential
  • Safety and effectiveness not established in pediatric patients

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Potential association of PPI therapy with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treated patients
  • Potential for methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat

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