OP-40 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (10 x 4: ৳ 320.00)
Strip Price: ৳ 32.00

Medicine Details

Category Details
Generic Omeprazole
Company Globe pharmaceuticals ltd
Also available as
Op 20 20 mg capsule Op 40 40 mg injection

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Specific dosages for benign gastric and duodenal ulcers
  • Dosage for NSAID-associated duodenal or gastric ulcers
  • Dosage for Gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen
  • Pediatric dosages for severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Monitoring and potential dose reduction for warfarin or phenytoin when co-administered
  • Increased plasma concentrations during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids

Contraindications

  • Known hypersensitivity to omeprazole
  • Need to exclude possibility of malignancy before treatment for suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin rash, urticaria, pruritus, photosensitivity, bullous eruption, and erythema multiforme
  • Reported gastrointestinal reactions like diarrhea, nausea/vomiting, flatulence, and abdominal pain
  • Reported neurological and psychotropic effects

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child observed in prospective epidemiological studies
  • Use during pregnancy considered safe
  • No information available on passage into breast milk or effects on the neonate
  • Breastfeeding should be discontinued if essential use of omeprazole

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term
  • Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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