Proceptin 40 mg/vial (IV Injection)

40 mg vial: ৳ 100.00

Medicine Details

Category Details
Generic Omeprazole
Company Beximco pharmaceuticals ltd
Also available as
Proceptin 20 mg capsule Proceptin 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4-8 weeks
  • Maintenance dose for recurrent duodenal ulcer 20 mg once daily
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg once daily for prophylaxis of acid aspiration during general anesthesia
  • 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen

Administration

  • Omeprazole IV injection should be given as a slow intravenous injection
  • Omeprazole IV infusion should be given over a period of 20-30 minutes or more
  • Reconstituted solutions should be used within specified timeframes

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 impacting elimination of diazepam, phenytoin, and warfarin
  • Possible interaction with Proceptin and clarithromycin
  • No evidence of interaction with various medications

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspected gastric ulcer unless malignancy is excluded

Side Effects

  • Well-tolerated with generally mild and reversible adverse reactions
  • Reports of skin rash, urticaria, pruritus, photosensitivity, and alopecia
  • Gastrointestinal reactions including diarrhea, headache, constipation, nausea/vomiting
  • Other reported reactions like dry mouth, dizziness, paraesthesia, and mental confusion
  • Reports of arthritic and myalgic symptoms, vision disturbance, and increased sweating
  • Observations of liver enzymes increases

Pregnancy & Lactation

  • No adverse effects indicated on pregnancy or health of the fetus/newborn child
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Breastfeeding discontinuation recommended if essential use of Omeprazole

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Proceptin
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally in long-term treatment
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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