Promezol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Sharif pharmaceuticals ltd
Also available as
Promezol 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days upon discontinuation

Dosage

  • Oral administration
  • IV injection
  • Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks
  • NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
  • Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks
  • Long-term management of acid reflux disease: 10-20 mg daily
  • Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
  • Prophylaxis of acid aspiration: 40 mg on the preceding evening
  • Zollinger-Ellison syndrome: Initially 60 mg once daily
  • Helicobacter pylori eradication regimen: Omeprazole is recommended at a dose of 20 mg twice daily
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • IV Injection
  • IV Infusion
  • Intravenous administration only
  • IV injection should be given as a slow intravenous injection
  • IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more
  • Reconstituted solution should not be mixed or co-administered with any other drug

Interactions

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of omeprazole and clarithromycin increased during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer where malignancy should be excluded before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea, headache, constipation, and nausea/vomiting
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Arthritic and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • Omeprazole can be used during pregnancy
  • Discontinuation of breast-feeding if the use of omeprazole is considered essential
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • PPI therapy may be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric biopsies from long-term treatment
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat

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