Propin 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.55 (20's pack: ৳ 151.00)

Medicine Details

Category Details
Generic Omeprazole
Company Hallmark pharmaceuticals ltd
Also available as
Propin 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration for various conditions and durations
  • Maintenance doses for recurrent duodenal ulcer
  • IV Injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux oesophagitis, Zollinger-Ellison syndrome
  • IV Infusion for appropriate conditions and durations
  • Directions for reconstitution and administration

Administration

  • IV injection for intravenous administration only
  • Slow intravenous injection for IV Injection
  • Intravenous infusion over a period of 20-30 minutes or more for IV Infusion
  • Specific instructions for reconstitution and usage

Interaction

  • Decreased intragastric acidity affecting the absorption of other medications
  • Metabolism through cytochrome P450 impacting the elimination of certain drugs
  • Monitoring and potential dose adjustment for medications like warfarin and phenytoin
  • Plasma concentration changes during concomitant administration of certain drugs
  • Impact on absorption of specific drugs
  • Increased bioavailability of digoxin due to increased intragastric pH

Contraindications

  • Known hypersensitivity to Omeprazole
  • Need to exclude possibility of malignancy in suspected gastric ulcer before treatment initiation

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, lightheadedness, feeling faint
  • Somnolence, insomnia, vertigo
  • Mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Various other isolated reported effects

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child based on studies
  • Use during pregnancy possible
  • No information available on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Potential association with increased risk for osteoporosis-related fractures
  • Occasional atrophic gastritis noted in long-term treatment
  • Possible impact on methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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