Regerd 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)

Strip Price: ৳ 50.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Novatek pharmaceuticals ltd
Also available as	Regerd 40 mg capsule Regerd 40 mg injection

Title

Regerd

Description

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually, over 3 to 5 days.

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Dosage

Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed

Administration

Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% Dextrose for infusion.

Interaction

Decreased intragastric acidity may reduce absorption of ketoconazole
Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin

Contraindications

Patients with known hypersensitivity to Omeprazole
When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with Omeprazole is instituted

Side Effects

Skin rash, urticaria, and pruritus
Diarrhoea and headache
Other gastrointestinal reactions including constipation and nausea/vomiting
Dizziness, somnolence, and insomnia

Pregnancy & Lactation

Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy.

Precautions & Warnings

Avoid concomitant use of clopidogrel and Regerd
Observational studies suggest that proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.