Seclo 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (12 x 10: ৳ 720.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Omeprazole
Company Square pharmaceuticals plc
Also available as
Seclo 40 mg capsule Seclo 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Helicobacter pylori eradication regimen dosage
  • Pediatric dosage for severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Preparation of IV injection solution
  • Preparation of IV infusion solution
  • Time duration for IV infusion
  • Instructions for use of IV infusion

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450
  • Potential delay in elimination of diazepam, phenytoin, and warfarin
  • Recommendation for monitoring patients receiving warfarin or phenytoin
  • Plasma concentration increase during concomitant administration with clarithromycin
  • Lack of evidence of interaction with various drugs
  • Increased bioavailability of digoxin with simultaneous treatment

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment initiation in suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin reactions (rash, urticaria, pruritus)
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia in isolated cases
  • Gastrointestinal reactions (diarrhea, headache, constipation, nausea, vomiting, flatulence, abdominal pain)
  • Other reported reactions (dry mouth, stomatitis, candidiasis, paraesthesia, dizziness, somnolence, insomnia, vertigo)

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child in prospective epidemiological studies
  • Safe use during pregnancy
  • Lack of information on passage into breast milk and effects on the neonate
  • Recommendation to discontinue breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Seclo
  • Potential association of PPI therapy with increased risk for osteoporosis-related fractures

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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