Som 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Marker pharma ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour of oral administration
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Oral administration for different conditions and durations
  • IV injection for different conditions and doses

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspected gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
  • Diarrhea, headache
  • Constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis
  • Paraesthesia, dizziness, lightheadedness, feeling faint
  • Somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
  • Hepatitis with or without jaundice, interstitial nephritis, hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
  • Safe use during pregnancy
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Discontinuation of breastfeeding if essential use of Omeprazole is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Som
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis in long-term treatment
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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