Xelopes 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.02 (12 x 10: ৳ 602.40)
Strip Price: ৳ 50.20

Medicine Details

Category Details
Generic Omeprazole
Company Beacon pharmaceuticals plc
Also available as
Xelopes 40 mg capsule Xelopes 40 mg injection

Indications

  • Treatment of gastric and duodenal ulcer
  • Treatment of NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Use of IV Injection
  • Use of IV Infusion
  • Reconstitution of IV injection
  • IV infusion over a period of 20-30 minutes
  • IV infusion over a period of 20-30 minutes or more
  • IV infusion over a period of at least 2 to 5 minutes

Interaction

  • Absorption of ketoconazole may be reduced during treatment
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin and warfarin
  • Monitoring of patients receiving warfarin or pheytoin
  • Plasma concentrations of Xelopes and clarithromycin are increased
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids
  • Increased bioavailability of digoxin

Contraindications

  • Known hypersensitivity to Omeprazole
  • Gastric ulcer suspected of malignancy

Side Effects

  • Skin rash, urticaria and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema and alopecia
  • Diarrhoea and headache
  • Constipation, nausea/vomiting, flatulence and abdominal pain
  • Dry mouth, stomatitis and candidiasis
  • Paraesthesia, dizziness, light headedness and feeling faint
  • Somnolence, insomnia and vertigo
  • Mental confusion, agitation, depression and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral oedema
  • Increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus
  • Use during pregnancy
  • No information available on passage into breast milk or effects on the neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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