Emep 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Metabolized in the liver by CYP enzymes
  • Plasma protein binding
  • Extensively metabolized in the liver
  • Plasma elimination half-life
  • Combination therapy with antimicrobials
  • Pharmacokinetic parameters for combination therapy

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD
  • Triple therapy dosage for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related dyspepsia
  • 20 mg once daily for duodenal ulcer
  • 20-40 mg once daily for gastric ulcer

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Preparation and administration of oral suspension
  • IV Injection preparation and administration

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of gastric acid secretion and drug absorption
  • Co-administration with clarithromycin
  • Absence of clinically significant interactions with certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion of esomeprazole in milk not studied
  • Discontinuation of breastfeeding if essential use of esomeprazole

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Administration one hour before meals
  • Use with antacids
  • Instructions for patients

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy in geriatric patients
  • No dosage adjustment for mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity
  • No specific antidote
  • Symptomatic and supportive treatment

Storage Conditions

  • Temperature and moisture conditions for storage

Chemical Structure

  • Molecular formula
  • Chemical structure image

Common Questions about Emep 20 mg Tablet

  • Uses of Emep 20 mg Tablet
  • Side effects of Emep 20 mg Tablet
  • Safety during pregnancy and breastfeeding
  • Time to start of action
  • Quick tips for usage

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