Esmax 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.50 (10 x 10: ৳ 850.00)
Strip Price: ৳ 85.00

Medicine Details

Category Details
Generic Esomeprazole
Company Concord pharmaceuticals ltd
Also available as
Esmax 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of Acid-related Dyspepsia
  • Treatment of Duodenal ulcer
  • Treatment of Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours
  • Distribution is 97% bound to plasma proteins
  • Extensively metabolized in the liver
  • Plasma elimination half-life is approximately 1-1.5 hours

Dosage

  • Oral dosage form
  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg Once Daily
  • Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 weeks
  • Duodenal ulcer: 20 mg Once Daily for 2-4 weeks
  • IV Injection or IV infusion for various conditions

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken with water or administered through a tube
  • IV Injection should be prepared with 0.9% Sodium Chloride and administered intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • May interfere with absorption of certain drugs where gastric pH is important
  • Increased plasma levels observed with certain co-administered drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Information for patients regarding capsule administration and use with antacids
  • Use in paediatric patients, geriatric patients, hepatic insufficiency, and renal insufficiency

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy between elderly and younger individuals
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Major signs of acute toxicity
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Compound Summary

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image provided

Common Questions about Esmax 20 mg Capsule

  • Definition and purpose of Esmax 20 mg Capsule
  • Uses of Esmax 20 mg Capsule
  • Common side effects of Esmax 20 mg Capsule
  • Safety of Esmax 20 mg Capsule during pregnancy and breastfeeding
  • Onset of action and quick tips for using Esmax 20 mg Capsule

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