Esmotac 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company Gaco pharmaceuticals ltd
Also available as
Esmotac 20 mg tablet

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Healing of Duodenal & Gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Extensively metabolized in the liver
  • Plasma elimination half-life is approximately 1–1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • Triple Therapy for Helicobacter Pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related Dyspepsia
  • 20-40 mg once daily for Duodenal & Gastric ulcers
  • IV Injection or IV infusion for specific cases

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension preparation and administration instructions
  • IV Injection solution preparation and administration guidelines

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Potential interference with CYP2C19
  • No clinically significant interactions with specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Antacids may be used while taking the medication

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy observed between elderly and younger individuals
  • Dosage adjustment for hepatic insufficiency
  • Effect on patients with renal impairment

Overdose Effects

  • Acute toxicity signs in animal studies
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Multiple uses of Esmotac 40 mg Tablet
  • Common side effects
  • Use during pregnancy or breastfeeding
  • Onset of action
  • Quick Tips for usage

Other

  • No clinically relevant interactions with specific drugs
  • Combination Therapy with Antimicrobials increases AUC and Cmax by certain percentages

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