Esogap 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Euro pharma ltd
Also available as
Esogap 40 mg tablet Esogap 20 mg capsule Esogap 40 mg capsule Esogap 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Peak plasma levels occur at approximately 1.5 hours
  • Systemic bioavailability is approximately 90%
  • 97% bound to plasma proteins
  • Metabolized in the liver by the cytochrome P450 enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • Dosage forms: Oral, IV Injection or IV infusion
  • Dose ranges for various indications
  • Dose adjustment for pediatric patients
  • Specific dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension administration
  • IV Injection preparation and administration

Interaction

  • Metabolism by CYP2C19 and CYP3A4
  • No clinically significant interactions with certain drugs
  • Interference with absorption of drugs where gastric pH is important

Contraindications

  • Known hypersensitivity to the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No well-controlled studies in pregnant women
  • No studies on excretion in milk
  • Breastfeeding discontinuation if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Guidance for patients with difficulty swallowing capsules
  • Use of antacids

Use in Special Populations

  • Safety and effectiveness for pediatric patients not established
  • No overall differences in safety and efficacy in geriatric use
  • No dosage adjustment for mild to moderate hepatic insufficiency

Overdose Effects

  • Acute toxicity signs
  • No specific antidote known
  • Symptomatic and supportive treatment
  • Consideration of multiple drug ingestion

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place, protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Usage as a proton pump inhibitor
  • Treatment for gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excess stomach acid
  • Common side effects
  • Pregnant or breastfeeding usage
  • Duration of onset
  • Quick Tips

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