Esolok 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (10 x 10: ৳ 900.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Ibn sina pharmaceuticals ltd
Also available as
Esolok 20 mg capsule Esolok 20 mg tablet Esolok 40 mg tablet Esolok 40 mg injection

Title

  • Esolok 40 mg Capsule

Categories

  • Medicine
  • Pharmaceutical

Description

  • A proton pump inhibitor for relieving chronic heartburn symptoms
  • Indicated for healing erosive esophagitis

Dimensions

  • Tablet or capsule: varies based on dosage form
  • Oral suspension: varies based on packet content

Color Options

  • White capsules

Functions

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related dyspepsia
  • Healing of duodenal and gastric ulcers
  • Reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy

Materials

  • Esomeprazole magnesium
  • Enteric-coated pellet formulation

Technical Specifications

  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Absorption time: approximately 1.5 hours after oral administration
  • Systemic bioavailability: approximately 90%
  • Plasma protein binding: 97%
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system

Design Elements

  • Enteric-coated pellets in capsules
  • Oral suspension packet

Usability Features

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Applesauce can be used to aid swallowing capsules
  • Can be administered through a nasogastric or gastric tube
  • IV injection prepared by adding 5 ml of 0.9% sodium chloride

Interactions

  • Metabolized by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • May interfere with the absorption of drugs influenced by gastric pH
  • No significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals
  • Antacids may be used while taking Esolok

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • No specific antidote known
  • Treatment should be symptomatic and supportive
  • Possibility of multiple drug ingestion should be considered

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Commonly Asked Questions

  • About uses, side effects, pregnancy & breastfeeding
  • Quick tips for usage and precautions

Administration

  • Variations in dosage form and administration based on specific indications

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