Esomep 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.02 (5 x 10: ৳ 251.00)
Strip Price: ৳ 50.20

Medicine Details

Category Details
Generic Esomeprazole
Company Aci limited
Also available as
Esomep 40 mg tablet Esomep 20 mg capsule Esomep 40 mg capsule Esomep 40 mg injection

Title

  • Esomep 20 mg Tablet

Categories

  • Medicines
  • Gastrointestinal Health

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid related Dyspepsia
  • Treatment of Duodenal & Gastric ulcers

Mode of Action

  • Proton pump inhibitor that suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor, providing better acid control than racemic proton pump inhibitors
  • Absorbed enterically
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage Forms

  • Tablet
  • Capsule
  • Oral Suspension
  • IV Injection
  • IV Infusion

Recommended Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori Eradication: Triple Therapy with Esomeprazole 40 mg Once Daily, Amoxicillin 1000 mg Twice Daily, Clarithromycin 500 mg Twice Daily for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg Once Daily
  • Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 weeks
  • Duodenal Ulcer: 20 mg Once Daily for 2-4 weeks
  • Gastric Ulcer: 20-40 mg Once Daily for 4-8 weeks
  • Dosage adjustments for Pediatric & Elderly patients

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension requires mixing with water and administration within 30 minutes
  • IV Injection should be administered over at least 3 minutes

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • No clinically significant interactions with certain drugs
  • Potential interference with gastric pH-dependent drug absorption

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No studies on excretion of esomeprazole in milk

Precautions & Warnings

  • Symptomatic response does not exclude presence of gastric malignancy
  • Special instructions for patients who have difficulty swallowing capsules
  • Use of antacids while taking Esomep

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy between elderly and younger individuals
  • No dosage adjustment for patients with mild to moderate hepatic insufficiency
  • Potential lack of alteration in pharmacokinetics in patients with renal impairment

Overdose Effects

  • Acute toxicity signs in animal studies
  • No reports of overdose
  • No specific antidote known

Storage Conditions

  • Store below 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Commonly Asked Questions

  • Information about Esomep 20 mg Tablet's uses and side effects
  • Safety and effectiveness for pregnant and breastfeeding individuals
  • Instructions for administration and quick tips

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