Esopin 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 4.02 (5 x 10: ৳ 201.00)
Strip Price: ৳ 40.20

Medicine Details

Category Details
Generic Esomeprazole
Company Hallmark pharmaceuticals ltd

Title

  • Esopin 20 mg Tablet

Categories

  • Heartburn Relief
  • GERD Medication
  • Erosive Esophagitis Treatment
  • Ulcer Healing

Description

  • Esomeprazole is a proton pump inhibitor used for the treatment of chronic heartburn, erosive esophagitis, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, dyspepsia, and ulcers.

Dimensions

  • N/A

ColorOptions

  • N/A

Functions

  • Relieves chronic heartburn
  • Heals erosive esophagitis
  • Maintains healing of erosive esophagitis
  • Eradicates Helicobacter pylori infection
  • Treats Zollinger-Ellison Syndrome
  • Manages acid-related dyspepsia
  • Heals duodenal and gastric ulcers

Materials

  • Esomeprazole magnesium

TechnicalSpecifications

  • Pharmacology:
    • Suppresses gastric acid secretion
    • Inhibits H+/K+-ATPase
    • Provides better acid control
    • Peak plasma levels occur at approximately 1.5 hours after oral administration
    • Metabolized by the liver
    • Systemic bioavailability is approximately 90%
    • Metabolized by cytochrome P450 enzymes
    • Plasma elimination half-life is approximately 1–1.5 hours
  • Dosage:
    • 20 mg or 40 mg oral dose for healing of erosive esophagitis
    • 20 mg oral dose for maintenance of healing of erosive esophagitis
    • 20 mg oral dose for symptomatic GERD
    • 40 mg oral dose for Helicobacter pylori eradication
    • 20-80 mg oral dose for Zollinger-Ellison Syndrome
    • 20-40 mg oral dose for acid-related dyspepsia
    • 20 mg oral dose for duodenal ulcer
    • 20-40 mg oral dose for gastric ulcer
    • Dosage for GERD with erosive esophagitis and risk reduction of rebleeding of ulcers via IV injection or infusion

DesignElements

  • Tablet or capsule form
  • Oral suspension
  • IV injection or infusion

UsabilityFeatures

  • Swallowed whole and taken one hour before a meal
  • Administration via nasogastric or gastric tube for oral suspension
  • IV injection must be administered intravenously over a period of at least 3 minutes

Absorption

  • Peak plasma levels occur at approximately 1.5 hours after oral administration

Distribution

  • 97% bound to plasma proteins
  • Apparent volume of distribution at steady state in healthy volunteers is approximately 16 L

Metabolism

  • Extensively metabolized in the liver by cytochrome P450 enzymes

Excretion

  • Less than 1% of parent drug is excreted in the urine
  • Approximately 80% of an oral dose is excreted as inactive metabolites in the urine

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • Potential interference with CYP2C19
  • No clinically significant interactions with specific drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

SideEffects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

PregnancyAndLactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

PrecautionsAndWarnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients regarding capsule administration and antacid use

SpecialPopulations

  • PediatricUse:
    • Safety and effectiveness not established in pediatric patients
  • GeriatricUse:
    • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • HepaticInsufficiency:
    • No dosage adjustment recommended for mild to moderate hepatic insufficiency
    • Dose should not exceed 20 mg daily in severe hepatic insufficiency
  • RenalInsufficiency:
    • Pharmacokinetics not expected to be altered in patients with renal impairment

OverdoseEffects

  • Toxic in rats at a dose 103 times the human dose on a body surface area basis
  • Signs of acute toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

StorageConditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

ChemicalStructure

  • MolecularFormula: C17H19N3O3S
  • ChemicalStructure: Image of chemical structure provided

CommonQuestions

  • WhatIsIt: Esopin 20 mg Tablet is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach
  • Uses:
    • Treats GERD, ulcers, and conditions involving excessive stomach acid
  • SideEffects:
    • Headaches
    • Diarrhea
    • Nausea
    • Gas
    • Stomach pain
    • Constipation
    • Dry mouth
  • PregnancyAndBreastfeeding: No side-effects but should be discussed with a doctor
  • OnsetOfAction: Usually starts within a few hours of taking
  • QuickTips:
    • Avoid eating late at night or before bedtime
    • Inform your doctor in case of persistent stomach issues or side effects
    • Long-term use can impact bone health and mineral levels, consult your doctor

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