Esoprol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Ziska pharmaceuticals ltd
Also available as
Esoprol 40 mg capsule Esoprol 40 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Healing of Duodenal & Gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • 97% bound to plasma proteins
  • Systemic bioavailability is approximately 90%
  • Peak plasma levels occur at approximately 1.5 hours

Dosage

  • Oral dosage form available
  • Dosage varies based on indication
  • IV Injection and IV infusion options available
  • Different dosages for adult and pediatric patients

Administration

  • Tablet or capsule should be swallowed whole
  • Oral suspension should be mixed with water
  • IV injection prepared by adding 0.9% Sodium Chloride
  • Specific instructions for administering through a nasogastric or gastric tube

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain drugs
  • Potential interference with drug absorption where gastric pH is important

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not rule out gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal effects observed in animal studies at high doses
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure available

Common Questions about Esoprol 20 mg Capsule

  • Proton pump inhibitor
  • Multiple uses including treatment of GERD, ulcers, and conditions involving excessive stomach acid
  • Common side effects include headaches, diarrhea, nausea, and constipation
  • Considerations for pregnant or breastfeeding individuals
  • Quick tips for usage and potential side effects

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