Esoprol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (4 x 8: ৳ 256.00)
Strip Price: ৳ 64.00

Medicine Details

Category Details
Generic Esomeprazole
Company Ziska pharmaceuticals ltd
Also available as
Esoprol 20 mg capsule Esoprol 40 mg injection

Title

Esoprol 40 mg Capsule

Categories

  • Medicine
  • Health
  • Pharmacology

Description

Esoprol 40 mg Capsule is a proton pump inhibitor (PPI) indicated for relieving chronic heartburn symptoms, healing erosive esophagitis, maintenance of healing, eradication of Helicobacter pylori infection, treating Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal and gastric ulcers.

Attributes

  • Indications:
    • Relieves chronic heartburn symptoms
    • Healing of erosive esophagitis
    • Maintenance of healing of erosive esophagitis
    • Eradication of Helicobacter pylori infection
    • Treatment for Zollinger-Ellison Syndrome
    • Manages acid-related dyspepsia
    • Treats duodenal and gastric ulcers
  • Pharmacology:
    • Proton pump inhibitor
    • Suppresses gastric acid secretion
    • Specific inhibition of the H+/K+-ATPase
    • Provides better acid control than racemic proton pump inhibitors
    • Absorption occurs approximately 1.5 hours after oral administration
    • Distribution: 97% bound to plasma proteins
    • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
    • Excretion: Less than 1% excreted in urine
  • Dosage:
    • Oral dosage form for various conditions such as healing of erosive esophagitis, symptomatic GERD, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal and gastric ulcers
    • IV Injection or IV infusion for GERD with Erosive Esophagitis in adult and pediatric patients, and risk reduction of rebleeding of Gastric or Duodenal Ulcers in adult patients
    • Specific dosages for body weights and age groups
  • Administration:
    • Tablet or capsule: Should be swallowed whole and taken one hour before a meal
    • Oral Suspension: Specific instructions for preparation and administration
    • IV Injection: Preparation of solution and administration guidelines
  • Interaction:
    • Metabolized in the liver by CYP2C19 and CYP3A4
    • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
    • Potential interactions with CYP2C19 and drugs impacted by gastric pH
  • Contraindications:
    • Contraindicated in patients with known hypersensitivity to any of the formulation
  • Side Effects:
    • Frequently occurring adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth
  • Pregnancy & Lactation:
    • No adequate and well-controlled studies in pregnant women
    • Animal studies showed no teratogenic effects
    • Excretion in milk not studied
    • Breastfeeding to be discontinued if essential
  • Precautions & Warnings:
    • Symptomatic response does not preclude the presence of gastric malignancy
    • Specific instructions for patients with difficulty swallowing capsules
  • Use in Special Populations:
    • Safety and effectiveness not established in pediatric patients
    • No overall differences in safety and efficacy observed between elderly and younger individuals
    • No dosage adjustment recommended for mild to moderate hepatic insufficiency
    • Pharmacokinetics not expected to be altered in patients with renal impairment
  • Overdose Effects:
    • Lethal effects observed in animal studies
    • No specific antidote known
    • Treatment to be symptomatic and supportive
  • Storage Conditions:
    • Store at a temperature not exceeding 30°C in a dry place
    • Protect from light and moisture
    • Keep out of reach of children
  • Chemical Structure:
    • Molecular Formula: C17H19N3O3S
    • Chemical Structure Image Provided
  • Common Questions about Esoprol 40 mg Capsule:
    • Information on usage, side effects, pregnancy & breastfeeding, onset of action, and quick tips

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