Esotid 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 14: ৳ 378.00)
Strip Price: ৳ 126.00

Medicine Details

Category Details
Generic Esomeprazole
Company Opsonin pharma ltd
Also available as
Esotid 20 mg tablet Esotid 20 mg capsule Esotid 40 mg capsule Esotid 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treating Zollinger-Ellison Syndrome
  • Treatment of acid related Dyspepsia
  • Healing of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of H+/K+-ATPase in gastric parietal cell
  • Absorption: Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Extensive metabolism in the liver by the cytochrome P450 enzyme system
  • Excretion: Less than 1% of parent drug excreted in the urine

Dosage

  • Oral dosage form: 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • Triple Therapy for Helicobacter pylori eradication: Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days
  • IV Injection or IV infusion for GERD with Erosive Esophagitis
  • Different dosages for Zollinger-Ellison Syndrome, acid-related Dyspepsia, duodenal ulcer, and gastric ulcer

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Should be mixed with water and taken immediately
  • IV Injection: Administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with specific CYP enzymes
  • Potential interference with CYP2C19
  • Inhibition of gastric acid secretion may interfere with the absorption of certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion in milk not studied

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Guidelines for patients who have difficulty swallowing capsules
  • Use of antacids while taking Esotid

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency

Overdose Effects

  • Lethal to rats at high doses
  • Reduced motor activity
  • Tremor
  • Ataxia
  • Intermittent clonic convulsions
  • No specific antidote

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Uses of Esotid 40 mg Tablet
  • Side effects of Esotid 40 mg Tablet
  • Pregnancy and breastfeeding precautions
  • Time taken for Esotid 40 mg Tablet to work

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