Esotid 40 mg/vial (IV Injection)

40 mg vial: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Opsonin pharma ltd
Also available as
Esotid 20 mg tablet Esotid 40 mg tablet Esotid 20 mg capsule Esotid 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor that suppresses gastric acid secretion
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Absorption peaks at approximately 1.5 hours after oral administration
  • Distribution: 97% bound to plasma proteins
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Less than 1% of parent drug is excreted in the urine

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Triple Therapy to reduce the risk of Duodenal Ulcer recurrence
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Zollinger-Ellison Syndrome: 20-80 mg once daily
  • IV Injection for Adult Patients: 20 mg or 40 mg once daily
  • IV Injection for Pediatric Patients: 10 mg or 20 mg once daily
  • IV Injection for Risk reduction of rebleeding of Gastric or Duodenal Ulcers: 80 mg

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken with water
  • IV Injection: administered intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit certain CYP enzymes
  • May interfere with the absorption of drugs where gastric pH is important
  • No clinically significant interactions with specific drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Adverse events reported: headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • No difference in types of related adverse events seen during maintenance treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Breast-feeding should be discontinued if the use of esomeprazole is considered essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Special instructions for patients who have difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness in pediatric patients have not been established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal to rats at a high dose
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: [Image]

Common Questions

  • Use for treating gastroesophageal reflux disease (GERD), ulcers, and conditions involving excess stomach acid
  • Common side effects include headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
  • Discontinuation of breast-feeding recommended if esomeprazole use is essential

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