Exium 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 9.00 (10 x 10: ৳ 900.00)
Strip Price: ৳ 90.00
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Radiant pharmaceuticals ltd |
Also available as |
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection
- Zollinger-Ellison Syndrome
- Acid related Dyspepsia
- Duodenal & Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppresses gastric acid secretion
- Enteric-coated pellet formulation
- Specific inhibition of the H+/K+-ATPase
- First single optical isomer of proton pump inhibitor
- Provides better acid control than racemic proton pump inhibitors
Absorption
- Peak plasma levels occur at approximately 1.5 hours
- Systemic bioavailability is approximately 90% compared to 64% after a single dose
- Plasma elimination half-life is approximately 1–1.5 hours
Metabolism
- Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
- The major part of metabolism is dependent upon the CYP2C19 isoenzyme
Excretion
- Less than 1% of parent drug is excreted in the urine
- Approximately 80% of an oral dose is excreted as inactive metabolites in the urine
Dosage
- 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
- 20 mg Once Daily for maintenance of healing of erosive esophagitis
- 20 mg Once Daily for symptomatic GERD for 4 Weeks
- Triple Therapy for Helicobacter Pylori eradication
- 20-80 mg for Zollinger-Ellison Syndrome
- 20-40 mg for Acid-related Dyspepsia for 2-4 weeks
- 20 mg Once Daily for Duodenal ulcer for 2-4 weeks
- 20-40 mg Once Daily for Gastric ulcer for 4-8 weeks
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral Suspension: To be taken with water and administered through a nasogastric or gastric tube as prescribed
- IV Injection: Must be administrated intravenously over a period of at least 3 minutes
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- No clinically relevant interactions with drugs metabolized by CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
- Potential interference with absorption of drugs where gastric pH is important
Contraindications
- Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhoea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Excretion in milk has not been studied
- Breast-feeding should be discontinued if essential
Precautions & Warnings
- Symptomatic response to therapy does not preclude the presence of gastric malignancy
- Instructions for patients on capsule administration and use of antacids
Use in Special Populations
- Safety and effectiveness in paediatric patients have not been established
- No overall differences in safety and efficacy observed between elderly and younger individuals
Overdose Effects
- Signs of acute toxicity in animal studies
- No specific antidote known
- Symptomatic and supportive treatment in case of overdose
Storage Conditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure: Image provided
Common Questions
- Exium is a proton pump inhibitor used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions related to excess stomach acid
- It may cause common side effects like headaches, diarrhea, and nausea
- Consult a doctor about the risks and benefits during pregnancy and breastfeeding
Quick Tips
- Exium is well-tolerated and provides relief for a long time
- Avoid eating late at night or before bedtime
- Consult your doctor for any persistent symptoms or side effects