Exor 40 mg/vial (IV Injection)

40 mg vial: ৳ 100.30

Medicine Details

Category Details
Generic Esomeprazole
Company Orion pharma ltd
Also available as
Exor 20 mg capsule Exor 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels at approximately 1.5 hours after oral administration
  • Systemic bioavailability approximately 90%
  • Metabolized in the liver by the CYP enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours
  • Combination therapy with antimicrobials
  • Increased exposure to 14-hydroxyclarithromycin during combination therapy
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4

Dosage

  • Oral dosage form
  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg once daily
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Duodenal ulcer: 20 mg once daily for 2-4 weeks
  • Gastric ulcer: 20-40 mg once daily for 4-8 weeks
  • IV Injection or IV Infusion for various conditions

Administration

  • Tablet or capsule: Swallowed whole and taken one hour before a meal
  • Oral Suspension: Mixed with water and ingested within 30 minutes
  • IV Injection: Administrated intravenously over a period of at least 3 minutes
  • Solution for injection with specific dilution and administration guidelines

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin not expected
  • Potential interference with absorption of drugs influenced by gastric pH
  • Effects on the pharmacokinetic profile of Exor in combination therapy with specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth
  • Similar types of related adverse events during maintenance and short term treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion of esomeprazole in milk not studied
  • Breast-feeding should be discontinued if essential use of esomeprazole

Precautions & Warnings

  • Symptomatic response does not rule out presence of gastric malignancy
  • Specific instructions for patients with difficulty in swallowing capsules
  • Usage of antacids while taking Exor

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences observed in safety and efficacy between elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Acute toxicity observed in animals
  • No specific antidote known
  • Treatment symptomatic and supportive
  • Possibility of multiple drug ingestion should be considered

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula : C17H19N3O3S

Common Questions about Exor 40 mg/vial Injection

  • Proton pump inhibitor (PPI)
  • Reduction of stomach acid production
  • Treatment for various conditions related to excessive stomach acid
  • Multiple uses including easing heartburn and relieving GERD symptoms
  • Effective prevention of erosive esophagitis recurrence
  • Common side effects including headache, diarrhea, nausea, and others
  • Absence of side-effects related to pregnancy or breastfeeding
  • Quick tips and recommendations for usage

Related Brands