Maxima 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 14: ৳ 980.00)
Strip Price: ৳ 98.00

Medicine Details

Category Details
Generic Esomeprazole
Company Acme laboratories ltd
Also available as
Maxima 40 mg capsule Maxima 40 mg injection Maxima 20 mg tablet Maxima 40 mg tablet

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Peak plasma levels occur at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolized in the liver by the cytochrome P450 enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours
  • Combination therapy with antimicrobials
  • AUC increased by 70% and Cmax by 18% during triple combination therapy
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Triple Therapy - Esomeprazole 40 mg Once Daily for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg once daily
  • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • Duodenal ulcer: 20 mg once daily for 2-4 weeks
  • Gastric ulcer: 20-40 mg once daily for 4-8 weeks
  • IV Injection: 20 mg or 40 mg once daily
  • IV Infusion for adults and pediatric patients

Administration

  • Tablet or capsule: should be swallowed whole and taken one hour before a meal
  • Oral Suspension: contents should be taken into a glass containing 15 ml of water
  • IV Injection: administered intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin
  • May interfere with the absorption of drugs where gastric pH is important for bioavailability

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion of esomeprazole in milk has not been studied

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals
  • Antacids may be used while taking Maxima
  • Information for patients regarding capsule administration

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Single oral dose lethal to rats at 510 mg/kg
  • Major signs of acute toxicity: reduced motor activity, changes in respiratory frequency, tremor, ataxia, intermittent clonic convulsions
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure image available

Common Questions

  • What is Maxima 20 mg Capsule?
  • What is Maxima 20 mg Capsule used for?
  • What are the side effects of Maxima 20 mg Capsule?
  • Pregnancy and breastfeeding considerations
  • Time taken for Maxima 20 mg Capsule to work
  • Quick Tips for taking Maxima 20 mg Capsule

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