Nexum 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.27

Medicine Details

Category Details
Generic Esomeprazole
Company Square pharmaceuticals plc
Also available as
Nexum 20 mg capsule Nexum 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Treatment of Duodenal and Gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Enteric-coated pellet formulation of esomeprazole magnesium

Dosage

  • Oral:
    • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
    • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
    • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
    • Helicobacter Pylori Eradication: Triple Therapy for 10 days
    • Zollinger-Ellison Syndrome: 20-80 mg Once Daily
    • Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 Weeks
    • Duodenal Ulcer: 20 mg Once Daily for 2-4 Weeks
    • Gastric Ulcer: 20-40 mg Once Daily for 4-8 Weeks
  • IV Injection or IV infusion:
    • Adult Patients (≥18 years): 20 mg or 40 mg once daily
    • Pediatric Patients: 10 mg - 20 mg once daily
    • Risk Reduction of Rebleeding of Gastric or Duodenal Ulcers: Initial dose of 80 mg followed by continuous infusion of 8 mg/h for 72 hours

Administration

  • Tablet or capsule should be swallowed whole
  • Oral Suspension should be taken with water and administered through a nasogastric or gastric tube
  • IV Injection should be administered intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes would be expected
  • May potentially interfere with the absorption of certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • The excretion of esomeprazole in milk has not been studied
  • Breastfeeding should be discontinued if the use of esomeprazole is considered essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Special administration instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Nexum

Use in Special Populations

  • Safety and effectiveness in pediatric patients have not been established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics in patients with renal impairment are not expected to be altered

Overdose Effects

  • Reduced motor activity
  • Changes in respiratory frequency
  • Tremor
  • Ataxia
  • Intermittent clonic convulsions
  • No specific antidote known

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Commonly Asked Questions

  • What is Nexum 40 mg/vial Injection?: Proton pump inhibitor used to treat conditions involving excessive stomach acid
  • What is Nexum 40 mg/vial Injection used for?: Eases heartburn, heals erosive esophagitis, prevents its recurrence, and treats various other conditions
  • What are the side effects of Nexum 40 mg/vial Injection?: Includes headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth
  • Can I take Nexum 40 mg/vial Injection if I am pregnant or breastfeeding?: Consider the risks and benefits after consulting a doctor
  • How long does it take for Nexum 40 mg/vial Injection to work?: Usually starts to work within a few hours of taking

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