Emez 40 mg (Capsule (Enteric Coated))
Medicine Details
| Category | Details |
|---|---|
| Generic | Omeprazole |
| Company | Edruc limited |
| Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Inhibitor of gastric acid secretion, blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system, onset of antisecretory effect occurs within one hour, maximum effect within two hours, inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for 4 weeks in duodenal ulceration
- 20 mg once daily for 4 weeks in NSAID-associated duodenal or gastric ulcer
- 20 mg once daily for 4 weeks in gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks in acid-related dyspepsia
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- 60 mg once daily for Zollinger-Ellison syndrome
Administration
- Omeprazole is for intravenous administration only
- IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
- IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more
Interaction
Decreased intragastric acidity may reduce the absorption of ketoconazole, possible delay in the elimination of diazepam, phenytoin, and warfarin, increased plasma concentrations of Emez and clarithromycin during concomitant administration
Contraindications
Omeprazole is contraindicated in patients with known hypersensitivity to it, and when gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with omeprazole is instituted
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, and peripheral edema
- Increased sweating, gynaecomastia, and leucopenia
- Thrombocytopenia, agranulocytosis, pancytopenia, and anaphylactic shock
- Malaise, fever, bronchospasm, and encephalopathy
- Hepatitis with or without jaundice, interstitial nephritis, and hepatic failure
Pregnancy & Lactation
Omeprazole can be used during pregnancy, but there is no information available on the passage of Omeprazole into breast milk or its effects on the neonate. Breast-feeding should be discontinued if the use of Omeprazole is considered essential
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Emez
- Observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Emez
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat, and keep out of the reach of children