Emez 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)

Medicine Details

Category	Details
Generic	Omeprazole
Company	Edruc limited
Also available as	Emez 20 mg capsule

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion, blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system, onset of antisecretory effect occurs within one hour, maximum effect within two hours, inhibition of secretion lasts up to 72 hours

Dosage

20 mg once daily for 4 weeks in duodenal ulceration
20 mg once daily for 4 weeks in NSAID-associated duodenal or gastric ulcer
20 mg once daily for 4 weeks in gastro-esophageal reflux disease
10-20 mg daily for long-term management of acid reflux disease
10-20 mg once daily for 2-4 weeks in acid-related dyspepsia
40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
60 mg once daily for Zollinger-Ellison syndrome

Administration

Omeprazole is for intravenous administration only
IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more

Interaction

Decreased intragastric acidity may reduce the absorption of ketoconazole, possible delay in the elimination of diazepam, phenytoin, and warfarin, increased plasma concentrations of Emez and clarithromycin during concomitant administration

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it, and when gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with omeprazole is instituted

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, and erythema multiforme
Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
Dry mouth, stomatitis, and candidiasis
Paraesthesia, dizziness, and feeling faint
Somnolence, insomnia, and vertigo
Reversible mental confusion, agitation, depression, and hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, and peripheral edema
Increased sweating, gynaecomastia, and leucopenia
Thrombocytopenia, agranulocytosis, pancytopenia, and anaphylactic shock
Malaise, fever, bronchospasm, and encephalopathy
Hepatitis with or without jaundice, interstitial nephritis, and hepatic failure

Pregnancy & Lactation

Omeprazole can be used during pregnancy, but there is no information available on the passage of Omeprazole into breast milk or its effects on the neonate. Breast-feeding should be discontinued if the use of Omeprazole is considered essential

Precautions & Warnings

Avoid concomitant use of clopidogrel and Emez
Observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures
Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Emez
Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat, and keep out of the reach of children