Esonix 20 mg (Oral Powder)

20 mg sachet: ৳ 7.00 (30's pack: ৳ 210.00)

Medicine Details

Category Details
Generic Esomeprazole
Company Incepta pharmaceuticals ltd
Also available as
Esonix 20 mg tablet Esonix 40 mg tablet Esonix 20 mg capsule Esonix 40 mg capsule Esonix 40 mg injection Esonix 20 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Treatment of acid related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Bioavailability is approximately 90%
  • Extensively metabolized in the liver
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • 40 mg Once Daily in combination therapy for Helicobacter Pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia
  • 20 mg once daily for Duodenal ulcer, 20-40 mg once daily for Gastric ulcer
  • Dosage for IV Injection and IV infusion for different conditions and age groups

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be prepared and administered as per instructions
  • IV Injection should be prepared and administered as per instructions

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibits gastric acid secretion
  • Potential interference with absorption of specific drugs
  • Clinically significant interactions with specific drugs
  • Combination Therapy with Clarithromycin can affect plasma levels of Esonix and 14-hydroxyclarithromycin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies reveal no teratogenic effects
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Specific instructions for administration to patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy for geriatric use
  • Dosage adjustment for severe hepatic insufficiency
  • No alteration in Pharmacokinetics for renal impairment

Overdose Effects

  • Lethal at high doses in animal studies
  • Signs of acute toxicity in high doses
  • No specific antidote known

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esonix 20 mg Powder

  • Description and usage of Esonix 20 mg Powder
  • Common side effects of Esonix 20 mg Powder
  • Recommendations for pregnant or breastfeeding individuals
  • Duration for effectiveness of Esonix 20 mg Powder
  • Quick tips for using Esonix 20 mg Powder

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