Nexe 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.50 (6 x 10: ৳ 390.00)
Strip Price: ৳ 65.00

Medicine Details

Category Details
Generic Esomeprazole
Company Apex pharmaceuticals ltd
Also available as
Nexe 20 mg tablet Nexe 40 mg capsule Nexe 40 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Management of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of H+/K+-ATPase
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Systemic bioavailability of approximately 90%
  • Extensive metabolism in the liver
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • Oral dosage form for various indications
  • IV Injection or IV infusion for specific conditions
  • Different doses based on age and weight

Administration

  • Swallowing whole tablet or capsule with water
  • Preparation and administration of oral suspension
  • Preparation and administration of IV injection
  • Guidelines for taking with or without meals

Interaction

  • Metabolism by CYP2C19 and CYP3A4
  • No clinically relevant interactions with specific drugs
  • Potential interference with drugs based on gastric pH

Contraindications

  • Hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Recommendation to discontinue breastfeeding if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Guidelines for patients with difficulty swallowing capsules
  • Permissible use of antacids

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy observed in geriatric patients
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • Unaltered pharmacokinetics in patients with renal impairment

Overdose Effects

  • Lethal dose observed in animal studies
  • Signs of acute toxicity in overdose cases
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place, protected from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: [Link to image]

Common Questions about Nexe 20 mg Capsule

  • Description of Nexe 20 mg Capsule as a proton pump inhibitor
  • Multiple uses of Nexe 20 mg Capsule
  • Common side effects of Nexe 20 mg Capsule
  • Guidance for pregnant or breastfeeding individuals
  • Expected time for Nexe 20 mg Capsule to start working
  • Quick Tips for using Nexe 20 mg Capsule

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