Esonix 20 mg/vial (IV Injection)

20 mg vial: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole
Company Incepta pharmaceuticals ltd
Also available as
Esonix 20 mg tablet Esonix 40 mg tablet Esonix 20 mg capsule Esonix 40 mg capsule Esonix 40 mg injection Esonix 20 mg powder

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid related Dyspepsia
  • Healing of Duodenal & Gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Provides better acid control than racemic proton pump inhibitors
  • Rapid absorption after oral administration
  • Extensive metabolism in the liver
  • Low plasma elimination half-life
  • Extensively bound to plasma proteins

Dosage

  • Multiple dosage forms - oral, IV injection, IV infusion
  • Different dosages for various indications and patient groups
  • Recommendations for adult and pediatric patients
  • Instructions for dosage adjustment based on conditions

Administration

  • Tablet or capsule should be swallowed whole
  • Instructions for oral suspension preparation and administration
  • Guidelines for IV injection and infusion preparation and administration

Interaction

  • Extensive metabolism by CYP2C19 and CYP3A4
  • Inhibition of specific CYP enzymes
  • Potential interference with drug absorption

Contraindications

  • Known hypersensitivity to the formulation

Side Effects

  • Frequently occurring adverse events like headache, diarrhea, nausea, etc.
  • Similar adverse events during short term and maintenance treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Lack of information on excretion in milk

Precautions & Warnings

  • Symptomatic response does not rule out gastric malignancy
  • Special instructions for patients with difficulty swallowing capsules
  • Allowance for use of antacids alongside esomeprazole

Use in Special Populations

  • Lack of established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy in geriatric use
  • Guidance for dosage adjustment in hepatic and renal insufficiency

Overdose Effects

  • Lethal dose in animal studies
  • Major signs of acute toxicity
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Temperature and environmental precautions

Chemical Structure

  • Molecular formula: C17H19N3O3S
  • Illustration of chemical structure

Common Questions

  • General information about esomeprazole
  • Specific uses of esomeprazole
  • Details on side effects
  • Safety considerations during pregnancy and breastfeeding
  • Expected time for esomeprazole to work
  • Quick tips for users

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