Avloclav 875 mg+125 mg (Tablet)

Indications

• Upper respiratory tract infections (including ENT)
• Lower respiratory tract infections
• Genito-urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Other infections

Composition

• 375 mg tablet: Amoxicillin 250 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
• 625 mg tablet: Amoxicillin 500 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
• 1 gm tablet: Amoxicillin 875 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg Diluted Potassium Clavulanate BP
• Powder for Suspension: Amoxicillin 125 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP
• Powder for Suspension (Forte): Amoxicillin 400 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate BP
• 1.2 gm Injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)
• 0.6 gm injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 500) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg)

Pharmacology

• Broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms
• Susceptible to degradation by (3-lactamases
• Inactivation of a wide range of beta-lactamase enzymes
• Peak serum levels of both components occur about one hour after oral administration

Dosage

• Adults and children over 12 years
• Tablet: 625 mg Tablet every 12 hours or 375 mg Tablet every 8 hours for usual adult dose
• Suspension: 2 teaspoonful every 8 hours for children 6-12 years
• IV Injection: 1.2 gm every 8 hours for adults

Administration

• Oral dosage form can be taken without regard to meals
• IV injection is not suitable for intramuscular or subcutaneous administration
• Intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes)

Interaction

• Prolongation of bleeding time and prothrombin time reported in some patients receiving Co-amoxiclav
• Reduction of efficacy of oral contraceptives

Contraindications

• History of Penicillin hypersensitivity
• Possible cross-sensitivity with other beta-lactam antibiotics
• Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

• Diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting
• Hepatitis, cholestatic jaundice, Urticarial and erythematous rashes
• Angioedema and anaphylaxis reported

Pregnancy & Lactation

• Animal studies with orally and parenterally administered Co-amoxiclav have shown no teratogenic effect
• Trace quantities of Amoxicillin can be detected in breast milk during lactation

Precautions & Warnings

• Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction
• Dosage adjustment in case of patients with moderate or severe renal impairment

Use in Special Populations

• Dose adjustment in case of patients with renal impairment
• Monitoring of hepatic function at regular intervals

Overdose Effects

• Gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident in case of overdose

Therapeutic Class

• Broad spectrum penicillins

Reconstitution

• IV injection should not be reconstituted or mixed with certain solutions such as Dextrose solution, Sodium Bicarbonate solution, Protein Hydrolysates

Storage Conditions

• Should be stored below 25°C, protected from light and moisture
• Reconstituted suspension should be kept in the refrigerator (but not frozen) and used by 7 days

Related Brands

• Amoclav 875 mg+125 mg (Tablet) - techno-drugs-ltd
• Amoclav (1 gm+200 mg)/20 ml (IV Injection) - techno-drugs-ltd
• Amoclav (125 mg+31.25 mg)/5 ml (Powder for Suspension) - techno-drugs-ltd
• Amoclav 500 mg+125 mg (Tablet) - techno-drugs-ltd
• Amoclav Forte (400 mg+57.50 mg)/5 ml (Powder for Suspension) - techno-drugs-ltd