Virunil 500 mg/vial (IV Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Acyclovir injection
Company Globe pharmaceuticals ltd
Also available as
Virunil 250 mg injection

Title

  • Virunil Intravenous Infusion

Categories

  • Medicine
  • Antiviral

Description

  • Virunil IV Injection for Intravenous Infusion is indicated for the treatment of Herpes simplex virus and Varicella zoster virus infections. It exerts its antiviral effects by interfering with DNA synthesis and inhibiting viral replication. The dosage varies based on the specific infection and patient's immune status. It should be administered by slow intravenous infusion over a one-hour period. Storage conditions include keeping it at 15°C to 25°C, protected from light and moisture, and out of the reach of children.

Dimensions

  • N/A

Color Options

  • N/A

Functions

  • Treats acute clinical manifestations of Herpes simplex virus
  • Treats severe primary or non-primary genital herpes
  • Treats Varicella zoster virus infection
  • Treats Herpes zoster (shingles)
  • Treats Herpes simplex encephalitis

Materials

  • Acyclovir

Technical Specifications

  • Dosage of 5 mg/kg every 8 hours for Herpes simplex infection
  • Dosage of 10 mg/kg every 8 hours for Varicella zoster infection in immunocompromised patients
  • Dosage should be administered by slow intravenous infusion over a one-hour period
  • Storage temperature: 15°C to 25°C

Design Elements

  • N/A

Usability Features

  • Recommended for intravenous infusion only
  • Reconstitution involves the addition of Water for Injection or Sodium Chloride Intravenous Infusion (0.9% w/v)
  • Compatible with several infusion fluids such as Sodium Chloride Intravenous Infusion BP and Glucose Intravenous Infusion

Interaction

  • Co-administration of probenecid with Virunil has been shown to increase the mean Virunil half-life and area under the concentration time curve
  • Concurrent use of diuretics in patients over 60 years of age increases plasma levels of Virunil

Indications

  • Treats acute clinical manifestations of Herpes simplex virus in immunocompromised patients
  • Treats severe primary or non-primary genital herpes in immune competent patients
  • Treats Varicella zoster virus infection in immunocompromised patients
  • Treats Herpes zoster (shingles) in immune competent patients
  • Treats Herpes simplex encephalitis

Contraindications

  • Contraindicated in patients known to be hypersensitive to Acyclovir or Valacyclovir

Side Effects

  • Lethargy
  • Obtundation
  • Tremors
  • Confusion
  • Hallucinations
  • Agitation
  • Somnolence
  • Psychosis
  • Convulsions
  • Coma
  • Phlebitis
  • Nausea
  • Vomiting
  • Reversible increases in liver-related enzymes
  • Pruritus
  • Urticaria
  • Rashes
  • Increases in blood urea and creatinine
  • Local inflammatory reactions if infused into extracellular tissues

Pregnancy & Lactation

  • Pregnancy category B
  • Should not be used during pregnancy unless benefits clearly outweigh potential risks to the fetus
  • Should only be administered to nursing mothers if benefits to the mother outweigh potential risks to the baby
  • No experience of the effect of Acyclovir on human fertility

Precautions & Warnings

  • Intended for intravenous infusion only
  • Reconstituted solution should not be administered by mouth
  • Must be given over a period of at least one hour to avoid renal tubular damage
  • Should not be administered as a bolus injection
  • Must be accompanied by adequate hydration
  • Concomitant use of other nephrotoxic drugs, pre-existing renal disease, and dehydration increase the risk of further renal impairment

Use in Special Populations

  • Dose for children aged 1-12 years calculated on the basis of body surface area
  • No data available for geriatric use
  • Modifications in dosage suggested for patients with renal impairment

Overdose Effects

  • Results in elevations of serum creatinine, blood urea nitrogen, and subsequent renal failure
  • Neurological effects including confusion, hallucinations, agitation, seizures, and coma have been described in association with overdose

Therapeutic Class

  • Herpes simplex & Varicella-zoster virus infections

Duration of Treatment

  • Recommended for five to seven days in the treatment of most infections
  • At least ten days in the treatment of Herpes simplex encephalitis

Reconstitution

  • Each 250 mg vial should be reconstituted with 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0.9% w/v)
  • Each 500 mg vial should be reconstituted with 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0.9% w/v)

Storage Conditions

  • Store at 15°C to 25°C
  • Protected from light and moisture
  • Keep out of the reach of children

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