Avloclav (500 mg+100 mg)/10 ml (IV Injection)

Indications

• Treatment of upper respiratory tract infections
• Treatment of lower respiratory tract infections
• Treatment of genito-urinary tract infections
• Treatment of skin and soft tissue infections
• Treatment of bone and joint infections
• Treatment of other bacterial infections

Composition

• 375 mg tablet: Contains Amoxicillin 250 mg and Clavulanic Acid 125 mg
• 625 mg tablet: Contains Amoxicillin 500 mg and Clavulanic Acid 125 mg
• 1 gm tablet: Contains Amoxicillin 875 mg and Clavulanic Acid 125 mg
• Powder for Suspension: Contains Amoxicillin 125 mg and Clavulanic Acid 31.25 mg
• Powder for Suspension (Forte): Contains Amoxicillin 400 mg and Clavulanic Acid 57.5 mg
• 1.2 gm Injection: Contains Amoxicillin 1 gm and Clavulanate Potassium 200 mg
• 0.6 gm Injection: Contains Amoxicillin 500 mg and Clavulanate Potassium 100 mg

Pharmacology

• Broad spectrum bactericidal activity
• Degradation susceptibility to beta-lactamases
• Inactivation of beta-lactamase enzymes
• Peak serum levels after oral administration
• Optimized absorption at the start of a meal

Dosage

• Various dosages for different age groups
• Tablet dosing frequency and severity-based dosing
• Suspension dosing for children of different age groups
• IV Injection dosing for adults and children
• Increased dosages for more serious infections

Administration

• Oral dosage form without regard to meals
• Enhanced absorption when administered at the start of a meal
• IV injection over 2 minutes or slow intravenous infusion over 30 minutes
• Use of reconstituted vial within 20 minutes

Interaction

• Prolongation of bleeding time and prothrombin time
• Reduced efficacy of oral contraceptives
• Concomitant use of allopurinol
• Potential cross-sensitivity with other beta-lactam antibiotics

Contraindications

• History of Penicillin hypersensitivity
• Cross-sensitivity with other beta-lactam antibiotics
• Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

• Uncommon and transient side effects
• Gastrointestinal side effects reduced by taking with meals
• Rare occurrence of hepatitis and cholestatic jaundice
• Reports of urticarial and erythematous rashes
• Incidence of angioedema and anaphylaxis

Pregnancy & Lactation

• No teratogenic effect in animal studies
• Limited use in human pregnancy with no untoward effects
• Detection of trace quantities in breast milk

Precautions & Warnings

• Use with care in patients on anticoagulation therapy
• Dosage adjustment in severe hepatic dysfunction
• Adjustment needed in case of moderate or severe renal impairment

Use in Special Populations

• Dose adjustment for patients with renal impairment
• Hepatic function monitoring at regular intervals

Overdose Effects

• Unlikely occurrence of overdose problems
• Potential gastrointestinal symptoms and fluid/electrolyte imbalance
• Removal from circulation by haemodialysis

Therapeutic Class

• Broad spectrum penicillins

Reconstitution

• IV injection reconstitution with Water for Injection BP
• Incompatibility with certain fluids and substances
• Injection into the drip tubing of infusion fluids

Storage Conditions

• Storage below 25°C and protected from light and moisture
• Refrigeration of reconstituted suspension but not freezing
• Usage of reconstituted vial within 20 minutes

Related Brands

• Avloclav (1 gm+200 mg)/20 ml (IV Injection) - aci-limited
• Avloclav BID (400 mg+57.50 mg)/5 ml (Powder for Suspension) - aci-limited
• Onclav (125 mg+31.25 mg)/5 ml (Powder for Suspension) - one-pharma-ltd
• Onclav 500 mg+125 mg (Tablet) - one-pharma-ltd
• Demoxiclave 875 mg+125 mg (Tablet) - drug-international-ltd