Nexe 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Apex pharmaceuticals ltd
Also available as
Nexe 20 mg tablet Nexe 40 mg capsule Nexe 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Metabolized in the liver
  • Excreted in urine and faeces
  • Combination therapy with antimicrobials

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Different dosages for various indications
  • Dosage adjustment for pediatric patients
  • Risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Tablet or capsule should be swallowed whole
  • Oral Suspension instructions
  • IV Injection preparation and administration

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Likely not to inhibit certain CYP enzymes
  • Potential interference with CYP2C19
  • Interaction with clarithromycin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies reveal no teratogenic effects
  • Excretion in milk not studied
  • Breastfeeding to be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not rule out gastric malignancy
  • Special instructions for patients who have difficulty swallowing capsules
  • Use of antacids while taking the medication

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy in geriatric use
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency

Overdose Effects

  • Major signs of acute toxicity in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image provided

Common Questions about Nexe 40 mg/vial Injection

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  • Quick Tips for using Nexe 40 mg/vial Injection

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