Clacido (125 mg+31.25 mg)/5 ml (Powder for Suspension)

100 ml bottle: ৳ 220.00

Medicine Details

Category	Details
Generic	Amoxicillin clavulanic acid
Company	Healthcare pharmaceuticals ltd
Also available as	Clacido 500 mg injection Clacido 1 gm injection Clacido 875 mg tablet Clacido 250 mg tablet Clacido 500 mg tablet Clacido bid 400 mg suspension

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Genito-urinary tract infections
Skin and soft tissue infections
Bone and joint infections
Other infections

Composition

375 mg tablet: Amoxicillin 250 mg, Clavulanic Acid 125 mg
625 mg tablet: Amoxicillin 500 mg, Clavulanic Acid 125 mg
1 gm tablet: Amoxicillin 875 mg, Clavulanic Acid 125 mg
Powder for Suspension: Amoxicillin 125 mg, Clavulanic Acid 31.25 mg
Powder for Suspension (Forte): Amoxicillin 400 mg, Clavulanic Acid 57.5 mg
1.2 gm Injection: Amoxicillin Sodium 1 gm, Clavulanate Potassium 200 mg
0.6 gm injection: Amoxicillin Sodium 500 mg, Clavulanate Potassium 100 mg

Pharmacology

Pharmacodynamic properties: Bactericidal activity against Gram-positive & Gram-negative microorganisms
Pharmacokinetic properties: Optimized absorption at the start of a meal, low levels of serum binding

Dosage

Adults and children over 12 years:
- 625 mg Tablet every 12 hours
- 375 mg Tablet every 8 hours
- 1 gm Tablet every 12 hours
- 1 gm Tablet every 8 hours
Children 6-12 years:
- 2 teaspoonful every 8 hours
- 1 teaspoonful every 8 hours
Children below 1 year: 25 mg/kg/day in divided doses every 8 hours

Administration

Oral dosage form: May be taken without regard to meals, but absorption is enhanced when taken at the start of a meal
IV injection: Administered intravenously by injection (over 2 minutes) or slow intravenous infusion (30 minutes)

Interaction

May reduce the efficacy of oral contraceptives, potential interaction with allopurinol

Contraindications

History of Penicillin hypersensitivity
Cross-sensitivity with other beta-lactam antibiotics
Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

Uncommon and mainly of a mild and transitory nature, gastrointestinal side effects may be reduced by taking Co-amoxiclav at the start of meals

Pregnancy & Lactation

No teratogenic effect in animal studies, limited use in human pregnancy with no untoward effect, trace quantities detected in breast milk

Precautions & Warnings

Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction

Use in Special Populations

Dose adjustment required in case of renal or hepatic impairment

Overdose Effects

Unlikely to occur, may cause gastrointestinal symptoms and electrolyte imbalances

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection can be reconstituted by dissolving the powder in Water for Injection BP

Storage Conditions

Should be stored below 25°C, protected from light and moisture, reconstituted suspension should be kept in the refrigerator and used within 7 days