Asozit 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company The white horse pharmaceuticals ltd
Also available as
Asozit 20 mg capsule

Title

Asozit 40 mg Capsule

Categories

  • Medicine
  • Proton Pump Inhibitor
  • Gastrointestinal Health

Description

Asozit 40 mg Capsule is a proton pump inhibitor (PPI) indicated for the relief of chronic heartburn, healing of erosive esophagitis, maintenance of healing of erosive esophagitis, eradication of Helicobacter pylori infection, treatment of Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal and gastric ulcers, and reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy.

DosageForm

Oral capsule

DosageStrength

40 mg

PackagingSize

10 capsules per pack

ColorOptions

  • White

Dimensions

  • Length: 2 cm
  • Width: 2 cm
  • Height: 1 cm

ActiveIngredient

Esomeprazole

InactiveIngredients

  • Microcrystalline cellulose
  • Crospovidone
  • Magnesium stearate
  • Talc

Pharmacology

  • Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels occur at approximately 1.5 hours after oral administration

Absorption

Peak plasma levels (Cmax) occur at approximately 1.5 hours after oral administration

Distribution

  • PlasmaProteinBinding: 97%
  • ApparentVolumeOfDistribution: 16 L

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system

Excretion

  • PlasmaEliminationHalfLife: Approximately 1-1.5 hours
  • UrineExcretion: < 1%
  • FaecesExcretion: Approximately 80%
  • InactiveMetabolitesExcretion: Approximately 80% in urine, remainder in faeces

CombinationTherapy

  • TripleTherapyDuration: 10 days
  • Components:
    • Esomeprazole 40 mg once daily
    • Amoxicillin 1000 mg twice daily
    • Clarithromycin 500 mg twice daily

ModeOfAction

Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase

Indication

  • Relief of chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related dyspepsia
  • Treatment of duodenal and gastric ulcers

Administration

  • Oral administration
  • Swallowed whole
  • One hour before a meal

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • Potential interference with CYP2C19, the major metabolizing enzyme
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

SideEffects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

PregnancyAndLactation

  • StudiesInPregnantWomen: No adequate and well-controlled studies
  • AnimalStudies: No teratogenic effects observed
  • ExcretionInMilk: Not studied
  • RecommendationForBreastfeeding: Discontinue breastfeeding if essential

PrecautionsAndWarnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Tablets should be taken at least one hour before meals
  • Patients with difficulty swallowing can open capsules and swallow pellets with applesauce
  • Antacids may be used while taking Asozit

SpecialPopulations

  • PediatricUse: Safety and effectiveness not established
  • GeriatricUse: No overall differences in safety and efficacy observed between elderly and younger individuals
  • HepaticInsufficiency: No dosage adjustment recommended for mild to moderate insufficiency
  • RenalInsufficiency: Pharmacokinetics not expected to be altered in patients with renal impairment

OverdoseEffects

  • Lethal to rats at 103 times the human dose on a body surface area basis
  • Major signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, and clonic convulsions
  • No specific antidote known, treatment should be symptomatic and supportive

StorageConditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.

ChemicalStructure

  • MolecularFormula: C17H19N3O3S
  • Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

CommonlyAskedQuestions

  • Questions:
      • Question: What is Asozit 40 mg Capsule?
      • Answer: A proton pump inhibitor used to treat GERD, ulcers, and other conditions related to excessive stomach acid.
      • Question: What is Asozit 40 mg Capsule used for?
      • Answer: Relief of heartburn, healing erosive esophagitis, and preventing its recurrence.
      • Question: What are the side effects of Asozit 40 mg Capsule?
      • Answer: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth.
      • Question: Can I take Asozit 40 mg Capsule if I am pregnant or breastfeeding?
      • Answer: Talk to your doctor; no harmful effects reported in pregnant or breastfeeding individuals.
      • Question: How long does it take for Asozit 40 mg Capsule to work?
      • Answer: Usually starts to work within a few hours of taking it.
      • Question: Quick Tips
      • Answer:
        • Well-tolerated and provides long-lasting relief
        • Avoid eating late at night or before bedtime
        • Consult doctor if you develop specific symptoms
        • Potential for bone weakening with long-term use

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