Peristal 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Silco pharmaceutical ltd
Also available as
Peristal 10 mg tablet

Title

  • Peristal 5 mg/5 ml Suspension

Categories

  • Medicine
  • Pharmaceuticals
  • Healthcare

Description

  • A dopamine antagonist medication used to treat nausea and vomiting.

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Epigastric sense of fullness
  • Feeling of abdominal distension
  • Upper abdominal pain
  • Eructation
  • Flatulence
  • Early satiety
  • Heartburn
  • Non-ulcer dyspepsia
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

  • Dopamine antagonist
  • Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach
  • Gastroprokinetic action
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus

Dosage & Administration

  • Usual Dose (Adults): 10-20 mg every 6-8 hours daily
  • Maximum Dose (Adults): 80 mg daily
  • Dose for Children: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
  • By Rectum (Adults): 30-60 mg every 4-8 hours
  • Maximum Period of Treatment: 12 weeks

Interaction

  • Anticholinergic drugs may antagonize the effect of domperidone
  • Antacids and antisecretory drugs lower oral bioavailability
  • Concomitant use with CYP3A4 inhibitors may increase plasma levels
  • May influence absorption of concomitantly administered drugs

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction, or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena (rare)
  • Increased plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Use during the first trimester justified by anticipated therapeutic benefit
  • No evidence of increased risk of malformations in humans
  • Excreted in breast milk, caution advised for nursing mothers

Precautions & Warnings

  • Use with caution in children due to risk of extra-pyramidal reactions
  • Use with caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants with great caution and under close medical supervision
  • Use with caution in patients with hepatic impairment
  • Use with caution in patients with severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Activated charcoal recommended in case of overdosage

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light & moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Questions

  • Used to treat nausea and vomiting
  • Helps relieve indigestion
  • May cause dizziness and sleepiness
  • Avoid consuming alcohol while taking
  • Dry mouth may occur as a side effect
  • Do not take for longer than 7 days without consulting a doctor

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