Kacin 250 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 30.00 (2 x 5: ৳ 300.00)

Medicine Details

Category Details
Generic Amikacin
Company Aci limited
Also available as
Kacin 100 mg injection Kacin 500 mg injection

Title

  • Amikacin Sulfate Injection

Categories

  • Medicine
  • Pharmaceutical
  • Antibiotics
  • Aminoglycosides

Description

  • Amikacin Sulfate is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, bacterial septicemia, serious infections of the respiratory tract, bones and joints, central nervous system, skin and soft tissue, intra-abdominal infections, burns, postoperative infections, complicated and recurrent urinary tract infections, and staphylococci infections. It is a semi-synthetic aminoglycoside antibiotic with activity against various bacteria. The dosage varies for adults, children, neonates, premature children, and elderly and should be adjusted based on renal function. It can be administered intramuscularly or intravenously and used intraperitoneally. There are contraindications, interactions with other medications, potential side effects, implications during pregnancy and lactation, precautions related to renal function, and considerations for pediatric use. In case of overdose, peritoneal dialysis or hemodialysis may aid in the removal of the drug from the blood. It belongs to the therapeutic class of Aminoglycosides and should be stored below 30°C, away from light and moisture.

Dimensions

  • N/A

Color Options

  • N/A

Functions

  • Short-term treatment of serious infections
  • Bacterial septicemia treatment
  • Treatment of respiratory tract infections
  • Treatment of bone and joint infections
  • Treatment of central nervous system infections
  • Treatment of skin and soft tissue infections
  • Intra-abdominal infection treatment
  • Treatment of burns and postoperative infections
  • Treatment of complicated and recurrent urinary tract infections
  • Treatment of staphylococci infections

Materials

  • Amikacin Sulfate

Technical Specifications

  • Active against pseudomonas species
  • Active against Escherichia coli
  • Active against Proteus species
  • Active against Providencia species
  • Active against Klebsiella-Enterobacter species
  • Active against Acinetobacter species
  • Active against Citrobacter freundii

Design Elements

  • N/A

Usability Features

  • Intramuscular or intravenous administration
  • Intraperitoneal use
  • Peritoneal dialysis or hemodialysis for overdose or toxic reaction

Indications

  • Short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria
  • Effective in bacterial septicemia
  • Effective in serious infections of the respiratory tract, bones and joints, central nervous system, skin and soft tissue
  • Effective in intra-abdominal infections, burns, and postoperative infections
  • Effective in complicated and recurrent urinary tract infections
  • Effective in staphylococci infections

Pharmacology

  • Semi-synthetic aminoglycoside antibiotic
  • Active against pseudomonas species
  • Active against Escherichia coli
  • Active against Proteus species
  • Active against Providencia species
  • Active against Klebsiella-Enterobacter species
  • Active against Acinetobacter species
  • Active against Citrobacter freundii
  • Active against penicillinase and nonpenicillinase-producing Staphylococcus species
  • Active when other aminoglycosides are resistant

Dosage

  • 15 mg/kg/day in two equally-divided doses for adults and children
  • 100 mg recommended for accurate measurement of children's dose
  • Initial loading dose of 10 mg/kg followed by 15 mg/kg/day for neonates and premature children
  • Dosage adjustment for elderly based on renal function
  • Increased adult dose for life-threatening infections and/or those caused by Pseudomonas
  • Reduced dose for urinary tract infections other than pseudomonal infections
  • Dosage adjustment in impaired renal function

Administration

  • Intramuscular or intravenous administration for most infections
  • Intravenous route in life-threatening infections or when intramuscular route is not feasible
  • Intraperitoneal use as an irrigant
  • Concentration of 0.25% for intraperitoneal use

Interaction

  • Potentiation of myorelaxants effects
  • Avoidance of combination with other aminoglycoside antibiotics
  • Increased risk of ototoxicity with fast-acting diuretics
  • Increased risk of nephrotoxicity with Cephalosporins or Polymixins

Contraindications

  • Known history of hypersensitivity to Amikacin or any constituents of the injection

Side Effects

  • Tinnitus
  • Vertigo
  • Partial reversible or irreversible deafness
  • Skin rash
  • Drug fever
  • Headache
  • Paraesthesia
  • Nausea
  • Vomiting

Pregnancy & Lactation

  • Potential risk of ototoxicity in the fetus due to rapid placental crossing
  • No available information on safety during breastfeeding

Precautions & Warnings

  • High concentrations in the renal excretory system
  • Importance of hydration to minimize chemical irritation of renal tubules
  • Monitoring of renal function during treatment with aminoglycosides

Use in Special Populations

  • Safety and effectiveness not established in children or adolescents under 16 years

Overdose Effects

  • Peritoneal dialysis or hemodialysis for removal of Amikacin from the blood in case of overdose or toxic reaction

Therapeutic Class

  • Aminoglycosides

Storage Conditions

  • Keep below 30°C temperature
  • Away from light
  • Away from moisture
  • Keep out of reach of children

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