Clovir 500 mg/vial (IV Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Acyclovir injection
Company Ibn sina pharmaceuticals ltd
Also available as
Clovir 250 mg injection

Title

  • Clovir IV Injection for Intravenous Infusion

Category

  • Medicine
  • Pharmaceutical

Description

  • Acyclovir exerts its antiviral effects on Herpes simplex virus and Varicella zoster virus by interfering with DNA synthesis and inhibiting viral replication.

Indications

  • Treatment of acute clinical manifestations of Herpes simplex virus in immunocompromised patients
  • Treatment of severe primary or non-primary genital herpes in immune competent patients
  • Treatment of Varicella zoster virus infection in immunocompromised patients
  • Treatment of Herpes zoster (shingles) in immune competent patients who show very severe acute local or systemic manifestations of the disease
  • Treatment of Herpes simplex encephalitis

Pharmacology

  • Interferes with DNA synthesis and inhibits viral replication

Dosage

  • 5 mg/kg every 8 hours for Herpes simplex infection in normal or immunocompromised immune status
  • 5 mg/kg every 8 hours for very severe Herpes zoster infection (shingles) in normal immune status
  • 10 mg/kg every 8 hours for Varicella zoster infection in immunocompromised immune status
  • 10 mg/kg every 8 hours for Herpes simplex encephalitis in normal or immunocompromised immune status

Administration

  • Recommended to be administered for five to seven days in the treatment of most infections and for at least ten days in the treatment of Herpes simplex encephalitis
  • Should be administered by slow intravenous infusion over a one-hour period
  • Compatible with Sodium Chloride Intravenous Infusion BP and other specified infusion fluids
  • Contains no preservative and should not be refrigerated

Interaction

  • Co-administration of probenecid with Clovir has been shown to increase the mean Clovir half-life and the area under the concentration time curve

Contraindications

  • Contraindicated in patients known to be hypersensitive to Acyclovir or Valacyclovir

Side Effects

  • Lethargy
  • Obtundation
  • Tremors
  • Confusion
  • Hallucinations
  • Agitation
  • Somnolence
  • Psychosis
  • Convulsions
  • Coma
  • Phlebitis
  • Nausea
  • Vomiting
  • Reversible increases in liver-related enzymes
  • Pruritus
  • Urticaria
  • Rashes
  • Increases in blood urea and creatinine

Pregnancy & Lactation

  • Pregnancy Category B - should not be used during pregnancy unless benefits clearly outweigh potential risks to the fetus
  • Should only be administered to nursing mothers if the benefits to the mother outweigh the potential risks to the baby
  • No experience of the effect of Acyclovir on human fertility

Precautions & Warnings

  • Intended for intravenous infusion only and should not be used through any other route
  • Should not be administered by mouth and must be given over a period of at least one hour
  • Maximum urine concentration occurs within the first few hours following infusion, so attention should be given to establish sufficient urine flow during that period
  • Concomitant use of other nephrotoxic drugs, pre-existing renal disease and dehydration increase the risk of further renal impairment by Clovir

Use in Special Populations

  • Pediatric use - dose calculated based on body surface area
  • Geriatric use - special attention should be given to dosage reduction due to low creatinine clearance
  • In patients with renal impairment - dose modification based on creatinine clearance level

Overdose Effects

  • Resulted in elevations of serum creatinine and subsequent renal failure
  • Neurological effects including confusion, hallucinations, agitation, seizures, and coma
  • Adequate hydration essential to reduce possibility of crystal formation in the urine
  • Hemodialysis enhances the removal of Clovir from the blood

Therapeutic Class

  • Herpes simplex & Varicella-zoster virus infections

Duration of Treatment

  • Recommended for five to seven days in the treatment of most infections and for at least ten days in the treatment of Herpes simplex encephalitis

Reconstitution

  • Reconstituted with Water for Injection or Sodium Chloride Intravenous Infusion to specific concentrations

Storage Conditions

  • Store at 15°C to 25°C, protected from light and moisture, keep out of the reach of children

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