Kacin 100 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 20.00 (2 x 10: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amikacin |
| Company | Aci limited |
| Also available as |
Indications
- Treatment of serious infections due to susceptible strains of Gram-negative bacteria
- Effective in bacterial septicemia, respiratory tract infections, CNS infections, bone and joint infections, skin and soft tissue infections, intra-abdominal infections, burns, postoperative infections, urinary tract infections, staphylococci infections
Pharmacology
- Semi-synthetic aminoglycoside antibiotic
- Active against pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella-Enterobacter species, Acinetobacter species, Citrobacter freundii
- Active against penicillinase and nonpenicillinase-producing Staphylococcus species
Dosage
- Recommended adult dose: 15 mg/kg/day in two equally-divided doses
- Recommended neonates and premature children dose: initial loading dose of 10 mg/kg followed by 15 mg/kg/day
- Elderly dosage adjustment based on renal function
- Maximum total adult dose of 15g should not be exceeded
Administration
- Preferred intramuscular route for most infections
- Intravenous route may be used in life-threatening infections
- Intraperitoneal use as an irrigant after recovery from anesthesia
- Concentration of 0.25% for intraperitoneal use
Interaction
- Potentiation of effects with myorelaxants
- Avoid concurrent administration with other aminoglycoside antibiotics
- Increased risk of ototoxicity with fast acting diuretics
- Increased risk of nephrotoxicity with cephalosporins or polymixins
Contraindications
- Hypersensitivity to Amikacin or any constituents of the injection
Side Effects
- Tinnitus
- Vertigo
- Partial reversible or irreversible deafness
- Skin rash
- Drug fever
- Headache
- Paraesthesia
- Nausea
- Vomiting
Pregnancy & Lactation
- Rapid crossing of placenta into the fetal circulation and amniotic fluid
- Potential risk of ototoxicity in the fetus
- No information available regarding safety during breastfeeding
Precautions & Warnings
- Maintain hydration to minimize chemical irritation of renal tubules
- Stop treatment if azotemia increases
- Monitor renal function during treatment with aminoglycosides
Use in Special Populations
- Safety and effectiveness not established in children or adolescents under 16 years
Overdose Effects
- Peritoneal dialysis or hemodialysis aids in the removal of Kacin from the blood
Therapeutic Class
- Aminoglycosides
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children