Phylopen 250 mg (Capsule)

Unit Price: ৳ 8.00 (10 x 10: ৳ 800.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Flucloxacillin sodium
Company Square pharmaceuticals plc
Also available as
Phylopen ds 500 mg capsule Phylopen 125 mg suspension Phylopen forte 250 mg suspension Phylopen 500 mg injection

Title

  • Phylopen

Categories

  • Antibiotics
  • Medicine
  • Healthcare

Description

  • Phylopen is a bactericidal antibiotic used for the treatment of infections due to Gram-positive organisms, including penicillinase-producing staphylococci. It is effective in treating various conditions such as skin and soft tissue infections, respiratory tract infections, osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, and septicaemia among others.
  • Flucloxacillin, the active ingredient in Phylopen, acts by inhibiting the formation of the cell wall of bacteria and is particularly useful against penicillinase-producing staphylococci.
  • Phylopen is available for oral and parenteral administration. The dosage varies for adults, children aged 2-10 years, and children under 2 years. It is recommended to administer oral doses 1 hour before a meal.
  • Caution is advised when using Phylopen in patients with hepatic dysfunction or an allergic diathesis. Special consideration is required in severe renal failure. It is contraindicated in penicillin-hypersensitive patients. The drug is classified under penicillinase-resistant penicillins and has a US FDA Pregnancy Category of B. Caution is recommended when administering Phylopen to lactating mothers.
  • Common side effects may include gastrointestinal disturbances, rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice.

Indications

  • Treatment of skin and soft tissue infections
  • Treatment of respiratory tract infections
  • Treatment of osteomyelitis
  • Treatment of enteritis
  • Treatment of endocarditis
  • Treatment of urinary tract infection
  • Treatment of meningitis
  • Treatment of septicaemia
  • Prophylactic use during major surgical procedures

Pharmacology

  • Active against Gram-positive organisms
  • Little activity against Gram-negative bacilli
  • Inhibits formation of bacterial cell wall
  • Resists action of bacterial penicillinase
  • Bactericidal antibiotic
  • Interferes with peptidoglycan synthesis
  • Weakens bacterial cell wall
  • Results in cell rupture

Dosage

  • Oral administration for adults: 250 mg four times daily
  • Doubling of dosage in severe infections
  • Parenteral administration for adults: 250 mg-1 g four times daily
  • Specific dosages for children based on age

Administration

  • Oral doses should be administered 1 hour before a meal

Interaction

  • Concurrent use may result in increased levels of Phylopen in the blood for a prolonged period

Contraindications

  • Contraindicated in penicillin-hypersensitive patients

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Dyspepsia
  • Rashes
  • Urticaria
  • Purpura
  • Fever
  • Interstitial nephritis
  • Hepatitis
  • Cholestatic jaundice

Pregnancy & Lactation

  • US FDA Pregnancy Category B
  • Caution advised during lactation

Precautions & Warnings

  • Use with caution in patients with evidence of hepatic dysfunction
  • Caution in patients with allergic diathesis
  • Special consideration in severe renal failure

Use in Special Populations

  • Reduction in dose or extension of dose interval in severe renal failure

Therapeutic Class

  • Penicillinase-resistant penicillins

Reconstitution

  • Phylopen has been used in other routes in conjunction with systemic therapy
  • Administered by intraarticular injection, dissolved in 0.5% solution of lignocaine hydrochloride, and by intrapleural injection
  • Inhaled by nebuliser four times daily after dissolution in sterile water

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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