Phylopen 250 mg (Capsule)
Unit Price: ৳ 8.00 (10 x 10: ৳ 800.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Flucloxacillin sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Phylopen
Categories
- Antibiotics
- Medicine
- Healthcare
Description
- Phylopen is a bactericidal antibiotic used for the treatment of infections due to Gram-positive organisms, including penicillinase-producing staphylococci. It is effective in treating various conditions such as skin and soft tissue infections, respiratory tract infections, osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, and septicaemia among others.
- Flucloxacillin, the active ingredient in Phylopen, acts by inhibiting the formation of the cell wall of bacteria and is particularly useful against penicillinase-producing staphylococci.
- Phylopen is available for oral and parenteral administration. The dosage varies for adults, children aged 2-10 years, and children under 2 years. It is recommended to administer oral doses 1 hour before a meal.
- Caution is advised when using Phylopen in patients with hepatic dysfunction or an allergic diathesis. Special consideration is required in severe renal failure. It is contraindicated in penicillin-hypersensitive patients. The drug is classified under penicillinase-resistant penicillins and has a US FDA Pregnancy Category of B. Caution is recommended when administering Phylopen to lactating mothers.
- Common side effects may include gastrointestinal disturbances, rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice.
Indications
- Treatment of skin and soft tissue infections
- Treatment of respiratory tract infections
- Treatment of osteomyelitis
- Treatment of enteritis
- Treatment of endocarditis
- Treatment of urinary tract infection
- Treatment of meningitis
- Treatment of septicaemia
- Prophylactic use during major surgical procedures
Pharmacology
- Active against Gram-positive organisms
- Little activity against Gram-negative bacilli
- Inhibits formation of bacterial cell wall
- Resists action of bacterial penicillinase
- Bactericidal antibiotic
- Interferes with peptidoglycan synthesis
- Weakens bacterial cell wall
- Results in cell rupture
Dosage
- Oral administration for adults: 250 mg four times daily
- Doubling of dosage in severe infections
- Parenteral administration for adults: 250 mg-1 g four times daily
- Specific dosages for children based on age
Administration
- Oral doses should be administered 1 hour before a meal
Interaction
- Concurrent use may result in increased levels of Phylopen in the blood for a prolonged period
Contraindications
- Contraindicated in penicillin-hypersensitive patients
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Dyspepsia
- Rashes
- Urticaria
- Purpura
- Fever
- Interstitial nephritis
- Hepatitis
- Cholestatic jaundice
Pregnancy & Lactation
- US FDA Pregnancy Category B
- Caution advised during lactation
Precautions & Warnings
- Use with caution in patients with evidence of hepatic dysfunction
- Caution in patients with allergic diathesis
- Special consideration in severe renal failure
Use in Special Populations
- Reduction in dose or extension of dose interval in severe renal failure
Therapeutic Class
- Penicillinase-resistant penicillins
Reconstitution
- Phylopen has been used in other routes in conjunction with systemic therapy
- Administered by intraarticular injection, dissolved in 0.5% solution of lignocaine hydrochloride, and by intrapleural injection
- Inhaled by nebuliser four times daily after dissolution in sterile water
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children