Revistar 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 60.23

Medicine Details

Category Details
Generic Flucloxacillin sodium
Company Biopharma limited
Also available as
Revistar 250 mg capsule Revistar 500 mg capsule

Title

  • Revistar (Flucloxacillin)

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Description

  • Revistar is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by penicillinase producing staphylococci. It is active against Gram-positive organisms including penicillinase producing strains. It has little activity against Gram-negative bacilli. Revistar is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci.
  • Oral doses should be administered 1 hour before meal.
  • Concurrent use of Revistar and may result in increased level of Revistar in blood for prolonged period.
  • Revistar should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with an allergic diathesis.
  • In severe renal failure (creatinine clearance < 10 ml/min), a reduction in dose or an extension of dose interval should be considered.
  • Keep in a dry place away from light and heat. Keep out of the reach of children.

Formulation

  • Oral administration
  • Parenteral administration
  • Intraarticular injection
  • Intrapleural injection
  • Inhalation by nebuliser

Dosage

  • Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
  • Children (2-10 years): 1/2 of adult dose. Children (Under 2 years): 1/4 of adult dose.
  • Adult or Elderly: Intramuscular Injection: 250 mg four times daily. Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion. All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis. Children: 2-10 years: half of the adult dose. Under 2 years: a quarter of the adult dose.

Indications

  • Skin and soft tissue infections
  • Respiratory tract infections
  • Osteomyelitis
  • Enteritis
  • Endocarditis
  • Urinary tract infection
  • Meningitis
  • Septicaemia

Mode of Action

  • Inhibits the formation of cell wall of bacteria
  • Resists the action of bacterial penicillinase
  • Interferes with peptidoglycan synthesis
  • Weakens and ruptures bacterial cell wall

Interaction

  • Concurrent use of Revistar and may result in increased level of Revistar in blood for prolonged period.

Contraindications

  • Flucloxacillin is contraindicated in penicillin hypersensitive patients.

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Rashes
  • Urticaria
  • Purpura
  • Fever
  • Interstitial nephritis
  • Hepatitis
  • Cholestatic jaundice
  • Minor gastrointestinal disturbances

Pregnancy & Lactation

  • US FDA Pregnancy Category of Flucloxacillin is B
  • Caution should be exercised when Flucloxacillin is administered to a lactating mother.

Precautions & Warnings

  • Revistar should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with an allergic diathesis.

Use in Special Populations

  • In severe renal failure (creatinine clearance < 10 ml/min), a reduction in dose or an extension of dose interval should be considered.

Therapeutic Class

  • Penicillinase-resistant penicillins

Reconstitution

  • Used in other routes in conjunction with systemic therapy
  • Administered in a dose of 250 mg to 500 mg daily by intraarticular injection
  • Administered by intrapleural injection in a dose of 250 mg daily
  • Dissolved in 3 ml of sterile water and inhaled by nebuliser four times daily.

Storage Conditions

  • Keep in a dry place away from light and heat. Keep out of the reach of children.

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