Ceftax 1 gm/10 ml (IM/IV Injection)

1 gm vial: ৳ 132.50

Medicine Details

Category Details
Generic Cefotaxime
Company Opsonin pharma ltd
Also available as
Ceftax 250 mg injection Ceftax 500 mg injection

Title and Category

  • Ceftax 3rd Generation Cephalosporin
  • Antibiotic Medication

Indications

  • Septicaemia treatment
  • Respiratory tract infections treatment
  • Urinary tract infections treatment
  • Soft-tissue infections treatment
  • Bone and joint infections treatment
  • Obstetric and gynaecological infections treatment
  • Gonorrhoea treatment
  • Bacterial meningitis treatment
  • Postoperative infection prophylaxis

Pharmacology

  • Binds to penicillin binding proteins
  • Inhibits final transpeptidation step of peptidoglycan synthesis
  • Broad spectrum bactericidal
  • Active against gram-negative organisms
  • Activity against gram-positive bacteria

Dosage and Administration

  • Recommended dosage for mild to moderate infections in adults: 1 gm every 12 hours
  • Dosage variation according to severity of infection
  • Children dosage range: 100-150 mg/kg/day in 2 to 4 divided doses
  • Neonates recommended dosage: 50 mg/kg/day in 2 to 4 divided doses
  • Single dose of 500 mg for gonorrhoea

Interaction

  • Increased nephrotoxicity with concomitant administration of cephalosporins and aminoglycoside antibiotics

Contraindications

  • Hypersensitivity to cefotaxime or cephalosporins

Side Effects

  • Infrequent and mild adverse reactions
  • Effects include candidiasis, rashes, fever, transient rises in liver enzymes, diarrhoea
  • Pseudomembranous colitis may rarely occur
  • Rare changes in renal function with high doses
  • Hypersensitivity reactions reported

Pregnancy and Lactation

  • Safety not established in human pregnancy
  • Excretion in milk

Precautions and Warnings

  • Prescribed with caution in individuals with history of gastrointestinal disease
  • Dosage adjustment for patients with renal insufficiency
  • No evidence supporting necessity of changing the dosage in patients with renal dysfunction

Use in Special Populations

  • Dosage adjustment in severe renal failure
  • Renal impairment dosage adjustment
  • Further dosage adjustment according to infection course and patient's general condition

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store below 25°C, protected from light and moisture
  • Use reconstituted solution immediately
  • Reconstituted solution stable for up to 24 hours if stored between 2°C to 8°C

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