Amoclav 500 mg+125 mg (Tablet)

Unit Price: ৳ 28.00 (3 x 6: ৳ 504.00)
Strip Price: ৳ 168.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Techno drugs ltd
Also available as
Amoclav 875 mg tablet Amoclav 1 gm injection Amoclav 125 mg suspension Amoclav forte 400 mg suspension

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Genito-urinary tract infections
  • Skin and soft tissue infections
  • Bone and joint infections
  • Other infections

Composition

  • 375 mg tablet: Amoxicillin 250 mg + Clavulanic Acid 125 mg
  • 625 mg tablet: Amoxicillin 500 mg + Clavulanic Acid 125 mg
  • 1 gm tablet: Amoxicillin 875 mg + Clavulanic Acid 125 mg
  • Powder for Suspension: Amoxicillin 125 mg + Clavulanic Acid 31.25 mg
  • Powder for Suspension (Forte): Amoxicillin 400 mg + Clavulanic Acid 57.5 mg
  • 1.2 gm Injection: Amoxicillin 1 gm + Clavulanate Potassium 200 mg
  • 0.6 gm injection: Amoxicillin 500 mg + Clavulanate Potassium 100 mg

Pharmacology

  • Pharmacodynamic properties: Bactericidal activity against many Gram-positive & Gram-negative microorganisms
  • Pharmacokinetic properties: Peak serum levels occur about one hour after oral administration

Dosage

  • Adults and children over 12 years:
    • Tablet: 625 mg Tablet every 12 hours or 375 mg Tablet every 8 hours
    • For more severe infections: 1 gm Tablet every 12 hours or 625 mg Tablet every 8 hours
    • Suspension: Children 6-12 years - 2 teaspoonful every 8 hours

Administration

  • Oral dosage form: Can be taken without regard to meals
  • IV injection: Not suitable for intramuscular or subcutaneous administration

Interaction

  • Prolongation of bleeding time and prothrombin time reported
  • May reduce the efficacy of oral contraceptives

Contraindications

  • History of Penicillin hypersensitivity
  • Contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Diarrhoea
  • Indigestion
  • Nausea
  • Vomiting
  • Candidiasis
  • Hepatitis
  • Cholestatic jaundice
  • Urticarial and erythematous rashes
  • Angioedema and anaphylaxis reported

Pregnancy & Lactation

  • Animal studies show no teratogenic effect
  • Use not recommended in pregnancy unless essential

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy
  • Dosage adjustment in patients with moderate or severe renal impairment

Use in Special Populations

  • Dose adjustment for patients with renal impairment

Overdose Effects

Unlikely to occur, gastrointestinal symptoms and fluid/electrolyte balance disturbance may be evident

Therapeutic Class

Broad spectrum penicillins

Reconstitution

  • IV injection: Reconstituted in 20 ml Water for Injection BP, should not be mixed with certain solutions

Storage Conditions

Stored below 25°C, protected from light and moisture

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