Clamox (500 mg+100 mg)/10 ml (IV Injection)

600 mg vial: ৳ 140.53

Medicine Details

Category	Details
Generic	Amoxicillin clavulanic acid
Company	Opsonin pharma ltd
Also available as	Clamox 1 gm injection Clamox 125 mg suspension Clamox 875 mg tablet Clamox 250 mg tablet Clamox 500 mg tablet Clamox ds 400 mg suspension

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Genito-urinary tract infections
Skin and soft tissue infections
Bone and joint infections
Septic abortion
Puerperal sepsis
Intra-abdominal sepsis

Composition

375 mg tablet: Amoxicillin 250 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
625 mg tablet: Amoxicillin 500 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
1 gm tablet: Amoxicillin 875 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg Diluted Potassium Clavulanate BP
Powder for Suspension: Amoxicillin 125 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP
Powder for Suspension (Forte): Amoxicillin 400 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate BP
1.2 gm Injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)
0.6 gm injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 500) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg)

Pharmacology

Pharmacodynamic properties: Antibacterial combination of Amoxicillin and Clavulanic Acid
Pharmacokinetic properties: Optimized absorption at start of a meal, low serum binding, doubling dosage doubles serum levels

Dosage

Adults and children over 12 years
Children 6-12 years
Children 1-6 years
Children below 1 year
Children of 2 to 12 years
IV Injection dosage for adults and children

Administration

Oral dosage form, IV injection administration guidelines

Interaction

Prolongation of bleeding time
Reduced efficacy of oral contraceptives
Concomitant use of allopurinol

Contraindications

History of Penicillin hypersensitivity

Side Effects

Diarrhoea
Pseudomembranous colitis
Indigestion
Nausea
Vomiting
Candidiasis
Hepatitis
Cholestatic jaundice
Urticarial and erythematous rashes
Angioedema
Anaphylaxis

Pregnancy & Lactation

Limited data available on use in pregnancy and lactation

Precautions & Warnings

Use with care in patients on anticoagulation therapy
Dosage adjustment for severe hepatic dysfunction
Dosage adjustment for moderate or severe renal impairment

Use in Special Populations

Dose adjustment in renal impairment and hepatic impairment

Overdose Effects

Unlikely to occur, may result in gastrointestinal symptoms and fluid imbalance

Therapeutic Class

Broad spectrum penicillins

Reconstitution

Guidelines for IV injection reconstitution

Storage Conditions

Should be stored below 25°C, reconstituted suspension to be used within 7 days