Moxaclav (1 gm+200 mg)/20 ml (IV Injection)

1.2 gm vial: ৳ 300.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Square pharmaceuticals plc
Also available as
Moxaclav 875 mg tablet Moxaclav 125 mg suspension Moxaclav 250 mg tablet Moxaclav 500 mg tablet Moxaclav forte 400 mg suspension

Indications

  • Short-term treatment of bacterial infections
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Genito-urinary tract infections
  • Skin and soft tissue infections
  • Bone and joint infections
  • Pharmacological action against a broad spectrum of bactericidal activity

Composition

  • 375 mg tablet composition
  • 625 mg tablet composition
  • 1 gm tablet composition
  • Powder for Suspension composition
  • Powder for Suspension (Forte) composition
  • 1.2 gm Injection composition
  • 0.6 gm injection composition

Pharmacology

  • Antibacterial combination of Amoxicillin and Clavulanic Acid
  • Spectrum of bactericidal activity
  • Inactivation of beta-lactamase enzymes
  • Optimized absorption at the start of a meal

Dosage

  • Dosage for adults and children over 12 years
  • Recommended tablet dosage
  • Recommended suspension dosage
  • Recommended forte suspension dosage
  • Recommended IV injection dosage

Administration

  • Oral dosage form administration
  • Enhanced absorption with start of a meal
  • IV injection administration

Interaction

  • Prolongation of bleeding time
  • Reduction of oral contraceptives efficacy
  • Concomitant use of allopurinol
  • Data on concomitant use of Co-amoxiclav and allopurinol

Contraindications

  • Contraindicated for Penicillin hypersensitivity
  • Possible cross-sensitivity with other beta-lactam antibiotics
  • History of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side effects

  • Uncommon and mostly mild
  • Diarrhea
  • Pseudomembranous colitis
  • Indigestion
  • Nausea
  • Vomiting
  • Candidiasis
  • Hepatitis
  • Cholestatic jaundice
  • Urticarial and erythematous rashes
  • Erythema multiforme
  • Stevens-Johnson Syndrome
  • Exfoliative dermatitis
  • Angioedema
  • Anaphylaxis

Pregnancy lactation

  • No teratogenic effect observed in animal studies
  • Limited use in human pregnancy
  • Detection of Amoxicillin in breast milk during lactation

Precautions warnings

  • Caution in patients on anticoagulation therapy
  • Caution in patients with severe hepatic dysfunction
  • Dosage adjustment for moderate or severe renal impairment
  • Maintenance of adequate fluid intake and urinary output

Special populations

  • Dose adjustment for renal impairment
  • Dose adjustment in hepatic impairment

Overdose effects

  • Unlikely to occur
  • Gastrointestinal symptoms
  • Disturbance of fluid and electrolyte balances

Therapeutic class

  • Broad spectrum penicillins

Reconstitution

  • Reconstitution of IV injection
  • Incompatible reconstitution or mixing substances
  • Injection into infusion fluids

Storage conditions

  • Storage condition below 25°C
  • Protection from light and moisture
  • Refrigeration of reconstituted suspension
  • Time limit for reconstituted vial usage

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