Tyclav (1 gm+200 mg)/20 ml (IV Injection)

1.2 gm vial: ৳ 300.00

Medicine Details

Category	Details
Generic	Amoxicillin clavulanic acid
Company	Beximco pharmaceuticals ltd
Also available as	Tyclav 125 mg suspension Tyclav 500 mg injection Tyclav 875 mg tablet Tyclav 250 mg tablet Tyclav 500 mg tablet Tyclav bid 400 mg suspension

Indications

Short-term treatment of bacterial infections for upper respiratory tract infections, lower respiratory tract infections, genito-urinary tract infections, skin and soft tissue infections, bone and joint infections, and other infections

Composition

375 mg tablet
625 mg tablet
1 gm tablet
Powder for Suspension
Powder for Suspension (Forte)
1.2 gm Injection
0.6 gm injection

Pharmacology

Pharmacodynamic properties: Amoxicillin and Clavulanic Acid combination. Broad spectrum bactericidal activity. Clavulanic acid inactivates a wide range of beta-lactamase enzymes.
Pharmacokinetic properties: Peak serum levels occur about one hour after oral administration. Absorption is optimized at the start of a meal. Low levels of serum binding for both clavulanate and Amoxicillin.

Dosage

Adults and children over 12 years:
- Tablet: 625 mg every 12 hours or 375 mg every 8 hours for usual dose.
- Suspension: Varies based on age and severity of infection.
- Forte suspension: Daily dosage varies based on infection severity.
- IV Injection: Dosage varies for adults and children based on age and severity of infection.

Administration

Oral dosage form can be taken without regard to meals. IV injection should not be administered intramuscularly or subcutaneously.

Interaction

May prolong bleeding time and prothrombin time. May reduce efficacy of oral contraceptives. Concomitant use with allopurinol may increase the likelihood of allergic skin reactions.

Contraindications

History of Penicillin hypersensitivity. Cross-sensitivity with other beta-lactam antibiotics. Also contraindicated for patients with previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.

Side Effects

Diarrhoea
Pseudomembranous colitis
Gastrointestinal side effects may be reduced by taking Co-amoxiclav at the start of meals.
Hepatitis
Cholestatic jaundice
Urticarial and erythematous rashes
Angioedema
Anaphylaxis

Pregnancy & Lactation

Not recommended in pregnancy unless essential. Trace quantities can be detected in breast milk during lactation.

Precautions & Warnings

Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction. Dosage should be adjusted for patients with moderate or severe renal impairment.

Use in Special Populations

Dose adjustment in case of patients with renal impairment or hepatic impairment.

Overdose Effects

Unlikely, may lead to gastrointestinal symptoms and fluid-electrolyte imbalances. May be removed from circulation by hemodialysis.

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection can be reconstituted with Water for Injection BP. Should not be mixed with certain fluids for injection. Reconstituted solution may be injected into the drip tubing of infusion fluids over 3-4 minutes.

Storage Conditions

Should be stored below 25°C, protected from light and moisture. Reconstituted suspension should be refrigerated (not frozen) and used within 7 days. Reconstituted vial must be used within 20 minutes.