Tyclav 875 mg+125 mg (Tablet)

Indications

• Upper respiratory tract infections (including ENT)
• Lower respiratory tract infections
• Genito-urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Other infections

Composition

• 375 mg tablet: Amoxicillin 250 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
• 625 mg tablet: Amoxicillin 500 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
• 1 gm tablet: Amoxicillin 875 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg Diluted Potassium Clavulanate BP
• Powder for Suspension: Amoxicillin 125 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP
• Powder for Suspension (Forte): Amoxicillin 400 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate BP
• 1.2 gm Injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)
• 0.6 gm injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 500) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg)

Pharmacology

• Pharmacodynamic properties: Broad spectrum of bactericidal activity
• Pharmacokinetic properties: Closely matched pharmacokinetics of the two components

Dosage

• Adults and children over 12 years:
  • Tablet: 625 mg every 12 hours or 375 mg every 8 hours
  • Suspension: Varies with age and severity of infection
  • Forte suspension: Varies with age and severity of infection
  • IV Injection: Varies with age and severity of infection
• Children of 2 to 12 years:
  • Mild to moderate infections: Suspension dosage varies with age
  • Serious infections: Forte Suspension dosage varies with age

Administration

Oral dosage form can be taken without regard to meals. IV injection for intravenous use only.

Interaction

• Prolongation of bleeding time and prothrombin time
• Reduction in efficacy of oral contraceptives
• Concomitant use of allopurinol

Contraindications

History of Penicillin hypersensitivity or previous Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

• Diarrhoea
• Pseudomembranous colitis
• Indigestion
• Nausea
• Vomiting
• Candidiasis
• Hepatitis
• Cholestatic jaundice
• Urticarial and erythematous rashes
• Angioedema
• Anaphylaxis

Pregnancy & Lactation

• No teratogenic effect in animal studies
• Limited use in human pregnancy with no untoward effect
• Not recommended in pregnancy unless essential

Precautions & Warnings

• Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction
• Dosage adjustment for moderate or severe renal impairment

Use in Special Populations

• Dosage adjustment for renal impairment in adults and children
• Dose with caution in hepatic impairment

Overdose Effects

• Gastrointestinal symptoms
• Disturbance of fluid and electrolyte balances
• Potential removal by haemodialysis

Therapeutic Class

Broad spectrum penicillins

Reconstitution

• IV injection: Reconstituted by dissolving the powder in Water for Injection BP

Storage Conditions

Below 25°C, protected from light and moisture. Refrigeration of reconstituted suspension.

Related Brands

• Co-Clav (125 mg+31.25 mg)/5 ml (Powder for Suspension) - ad-din-pharmaceuticals-ltd
• Co-Clav 500 mg+125 mg (Tablet) - ad-din-pharmaceuticals-ltd
• Mimoxclav 500 mg+125 mg (Tablet) - albion-laboratories-limited
• Fortimox 500 mg+125 mg (Tablet) - kumudini-pharma-ltd
• Fimoxyclav ES (600 mg+42.9 mg)/5 ml (Powder for Suspension) - synovia-pharma-plc