Aumi 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Hudson pharmaceuticals ltd
Also available as

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer for 4-8 weeks
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease, in association with antimicrobial agents
  • 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year) for 4-12 weeks
  • IV Injection: 40 mg of Omeprazole to be given slowly (over a period of 5 minutes) as an intravenous injection, one hour before surgery

Administration

  • Omeprazole IV injection should be given as a slow intravenous injection
  • Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity may reduce the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations of Aumi and clarithromycin are increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment with omeprazole

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
  • Dry mouth, stomatitis, candidiasis, paraesthesia
  • Dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo
  • Reversible mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock
  • Malaise, fever, bronchospasm, encephalopathy, hepatitis with or without jaundice, interstitial nephritis, hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • Omeprazole can be used during pregnancy
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Aumi
  • Associated risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in patients treated long-term with Aumi
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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