Cosec 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.30

Medicine Details

Category Details
Generic Omeprazole
Company Drug international ltd
Also available as
Cosec 20 mg capsule Cosec 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
  • NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
  • Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks
  • Long-term management of acid reflux disease: 10-20 mg daily
  • Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
  • Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
  • Zollinger-Ellison syndrome: Initially 60 mg once daily
  • Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily

Administration

  • IV Injection for prophylaxis of acid aspiration
  • IV Injection for duodenal ulcer, gastric ulcer, or reflux esophagitis
  • IV Injection for Zollinger-Ellison syndrome
  • IV Injection guidelines for slow intravenous administration

Interaction

  • Decreased intragastric acidity affects absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Plasma concentrations of Cosec and clarithromycin are increased during concomitant administration
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
  • No evidence of an interaction with piroxicam, diclofenac, or naproxen

Contraindications

  • Known hypersensitivity to Omeprazole
  • Gastric ulcer when malignancy is suspected

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity and bullous eruption
  • Diarrhea and headache
  • Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light-headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
  • Omeprazole can be used during pregnancy
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Discontinuation of breast-feeding if essential use of Omeprazole is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Cosec
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treated patients
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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