Deu 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (48's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Monicopharma ltd
Also available as

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

Omeprazole is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. The onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours.

Dosage

  • 20 mg once daily for duodenal ulceration
  • 40 mg once daily for severe or recurrent cases of gastric ulceration
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for paediatric use in severe ulcerating reflux esophagitis

Administration

  • Omeprazole IV injection should be given as a slow intravenous injection over 2 to 5 minutes at a maximum rate of 4 ml/minute
  • Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more

Interaction

Omeprazole may interact with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, amoxicillin, metronidazole, piroxicam, diclofenac, naproxen, digoxin, and other drugs.

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it. When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment with omeprazole is instituted.

Side Effects

  • Skin rash
  • Urticaria
  • Pruritus
  • Photosensitivity
  • Diarrhoea
  • Headache
  • Constipation
  • Nausea/vomiting
  • Flatulence
  • Abdominal pain
  • Dry mouth
  • Stomatitis
  • Candidiasis
  • Paraesthesia
  • Dizziness
  • Somnolence
  • Insomnia
  • Vertigo
  • Mental confusion
  • Arthritic symptoms
  • Myalgic symptoms
  • Blurred vision
  • Taste disturbance
  • Peripheral edema
  • Increased sweating
  • Gynaecomastia
  • Leucopenia
  • Thrombocytopenia
  • Agranulocytosis
  • Pancytopenia
  • Anaphylactic shock
  • Malaise
  • Fever
  • Bronchospasm
  • Encephalopathy
  • Hepatitis
  • Interstitial nephritis
  • Hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • Omeprazole can be used during pregnancy
  • Breast-feeding should be discontinued if the use of Omeprazole is considered essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Omeprazole
  • PPI therapy may be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole
  • Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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